LARGE AMOUNTS OF NEOCORTICAL BETA-A4 DEPOSITS WITHOUT NEURITIC PLAQUES NOR TANGLES IN A PSYCHOMETRICALLY ASSESSED, NONDEMENTED PERSON
LARGE AMOUNTS OF NEOCORTICAL BETA-A4 DEPOSITS WITHOUT NEURITIC PLAQUES NOR TANGLES IN A PSYCHOMETRICALLY ASSESSED, NONDEMENTED PERSON
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DOI：
10.1016/0304-3940(90)90391-l
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发表时间：
1990-08-14
影响因子：
2.5
通讯作者：
HAUW, JJ
中科院分区：
文献类型：
--
作者：
DELAERE, P;DUYCKAERTS, C;HAUW, JJ
一位88岁的智力正常女性(幸福测试分数=27)在第一个颞回有大量(397个/mm2)抗-βA4血清染色的沉淀物。经Bodian‘’S银染、抗tau和抗成对螺旋丝抗体染色，切片上未见老年斑和神经原纤维缠结。βA4沉积频率由高到低依次为弥漫性斑块(64.8%)、星状斑块(24.4%)、原始斑块(10.2%)、典型斑块(0.6%)。未见致密斑块。弥漫性沉积以I、III和IV层为主。相反，罕见的经典斑块位于II和III层。刚果红染色未见淀粉样血管病变，免疫细胞化学显示管壁可见βA4沉积。这些数据表明，新皮质中严重的弥漫性βA4沉积不会导致痴呆。他们认为，由βA4淀粉样蛋白组成的老年斑和退行性轴突的发展不仅仅与弥漫的βA4沉积的密度有关。它也不依赖于神经组织的区域敏感性，因为βA4沉积见于高度脆弱的皮质区域。其他一些尚不清楚的因素似乎是必要的。此外，新皮质中βA4水平的测定不足以诊断阿尔茨海默型痴呆症。
An 88-year-old mentally normal woman (Blessed test score=27) had very large amounts (397/mm2) of deposits stained by anti-.beta.A4 serum in the first temporal gyrus. Senile plaques and neurofibrillary tangles were lacking on sections stained with the Bodian''s silver method, with anti-tau and anti-paired helical filament (anti-PHF) antibodies. The following .beta.A4 deposits were found in decreasing order of frequency: diffuse (64.8%), stellate (24.4%), primitive (10.2%), classic (0.6%) plaques. Compact plaques were not observed. Diffuse deposits predominated in layers I, III and IV. On the contrary, the rare classic plaques were located in layers II and III. No amyloid angiopathy was seen with Congo red stain although .beta.A4 deposits were seen in vessel walls with immunocytochemistry. These data indicate that severe diffuse .beta.A4 deposits in the neocortex do not induce dementia. They suggest that the development of senile plaques composed of .beta.A4 amyloid and of degenerating neurites is not related solely to the density of the diffuse .beta.A4 deposits. Nor does it depend on the regional susceptibility of the nervous tissue since .beta.A4 deposits were seen in highly vulnerable cortical areas. Some other, as yet unknown, factors seem necessary. In addition, determination of .beta.A4 level in the neocortex is not sufficient for the diagnosis of dementia of Alzheimer type.