Transcription Regulation System Mediated by Mechanical Operation of a DNA Nanostructure
Transcription Regulation System Mediated by Mechanical Operation of a DNA Nanostructure
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DOI：
10.1021/ja2074856
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发表时间：
2012-02-15
影响因子：
15
通讯作者：
Sugiyama, Hiroshi
中科院分区：
文献类型：
--
作者：
Endo, Masayuki;Miyazaki, Ryoji;Sugiyama, Hiroshi
设计并构建了一个由DNA纳米结构变化启动的转录调控系统。利用脚趾系统，特定的DNA链诱导管状结构的开放。通过添加专用于开放管状结构的DNA链，从纯化的管连接的dsDNA模板中观察到转录产物。
A transcription regulation system initiated by DNA nanostructure changes was designed and constructed. Using the toehold system, specific DNA strands induced the opening of the tubular structure. A transcription product from the purified tube-attached dsDNA template was observed by addition of DNA strands that were specific for opening the tubular structure.