TRABECULAR BONE-DENSITY AND LOADING HISTORY - REGULATION OF CONNECTIVE-TISSUE BIOLOGY BY MECHANICAL ENERGY
TRABECULAR BONE-DENSITY AND LOADING HISTORY - REGULATION OF CONNECTIVE-TISSUE BIOLOGY BY MECHANICAL ENERGY
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DOI：
10.1016/0021-9290(87)90058-3
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发表时间：
1987-01-01
影响因子：
2.4
通讯作者：
WHALEN, RT
中科院分区：
文献类型：
--
作者：
CARTER, DR;FYHRIE, DP;WHALEN, RT
在骨小梁应力/形态关系研究中考虑单一载荷条件的方法被扩展为包括骨在体内经历的多种载荷条件。骨的每日负载历史以应力大小或循环应变能密度和负载循环次数来表征。建立了局部骨表观密度和负荷历史之间的关系，假设骨量根据强度或能量考虑进行调整。描述了三种不同的骨维持标准，其制定基于：（1）连续模型有效应力，（2）连续模型疲劳损伤累积密度，以及（3）骨组织应变能密度。这些方法可用于预测骨内和骨间表观密度的变化。我们表明，所有三个标准都具有相似的数学形式，并且可能与在矿化组织中转移（耗散）的骨应变能的密度（或浓度）有关。这里开发的负荷历史和能量转移概念可以应用于结缔组织的生长、功能适应、损伤和老化的许多不同情况。
The method of considering a single loading condition in the study of stress/morphology relationships in trabecular bone is expanded to include the multiple loading conditions experienced by bone in vivo. The bone daily loading histories are characterized in terms of stress magnitudes or cyclic strain energy density and the number of loading cycles. Relationships between local bone apparent density and loading history are developed which assume that bone mass is adjusted in response to strength or energy considerations. Three different bone maintenance criteria are described which are formulated based upon: (1) continuum model effective stress, (2) continuum model fatigue damage accumulation density, and (3) bone tissue strain energy density. These approaches can be applied to predict variations in apparent density within bone and among bones. We show that all three criteria have similar mathematical forms and may be related to the density (or concentration) of bone strain energy which is transferred (dissipated) in the mineralized tissue. The loading history and energy transfer concepts developed here can be applied to many different situations of growth, functional adaptation, injury, and aging of connective tissues.