Using time-to-pregnancy data to study occupational exposures: methodology.
Using time-to-pregnancy data to study occupational exposures: methodology.
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DOI：
10.1016/0890-6238(88)90023-8
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发表时间：
1988-01-01
期刊：
影响因子：
--
通讯作者：
Baird, D D
中科院分区：
文献类型：
--
作者：
Baird, D D
职业和环境对生育力的影响大部分没有得到研究，部分原因是没有开发出敏感的研究方法。我们正在开发一种衡量生育能力的方法，每月怀孕的概率，通过研究怀孕的时间，每对夫妇怀孕所需的非避孕月经周期的数量。这种生殖损害的衡量标准与其他因素（如自然流产）的关系尚不清楚。来自两个来源的初步数据表明，生育能力降低与自然流产风险增加的相关性并不高，尽管毒理学文献的预测与此相反。目前的牙科助理的职业暴露的研究将解决数据质量的问题，通过提供从邮件问卷和电话采访非常详细的数据，从电话采访的简短答复的比较。本研究还将允许估计两种潜在选择偏倚的大小：仅选择计划妊娠（意外妊娠的妊娠时间数据没有意义），以及选择高度不育和不育夫妇（当研究当前或既往妊娠的女性时，不育夫妇根本不代表，高度不育夫妇代表性不足）。
Occupational and environmental influences on fertility are for the most part unstudied, partly because sensitive methods for studying them have not been developed. We are developing a measure of fecundability, the monthly probability of pregnancy, by studying time to pregnancy, the number of noncontracepting menstrual cycles each couple requires to conceive. The relationship of this measure of reproductive impairment with others, such as spontaneous abortion, is not known. Preliminary data from two sources suggest that reduced fertility is not highly correlated with increased risk of spontaneous abortion, despite predictions to the contrary from the toxicology literature. A current study of occupational exposures of dental assistants will address questions of data quality by providing comparisons of brief responses from mail questionnaires and telephone interviews with very detailed data from telephone interviews. This study also will allow estimation of the magnitude of two potential selection biases: selection of only planned pregnancies (time-to-pregnancy data for accidental pregnancies are not meaningful), and selection against highly infertile and sterile couples (when studying currently or previously pregnant women, sterile couples are not represented at all and highly infertile couples are underrepresented).