A comparison of two progestins on myocardial ischemia-reperfusion injury in ovariectomized monkeys receiving estrogen therapy.
A comparison of two progestins on myocardial ischemia-reperfusion injury in ovariectomized monkeys receiving estrogen therapy.
复制标题
两种孕激素对接受雌激素治疗的去势猴心肌缺血再灌注损伤的比较。
DOI：
10.1097/00019501-200508000-00007
复制
发表时间：
2005
影响因子：
1.8
通讯作者：
Vinten-Johansen,Jakob
中科院分区：
文献类型：
--
作者：
Suparto,IrmaH;KoudyWilliams,J;Fox,JamieL;Vinten-Johansen,Jakob
ObjectiveIt has been reported that the progestin medroxyprogesterone acetate (MPA), but not norethindrone acetate (NETA), inhibits the beneficial vascular effects of post-menopausal estrogen therapy, but their effects on the myocardium are unclear. The goal of this study is to compare the effects of these two progestins on post-ischemic myocardial damage.MethodsOvariectomized monkeys were fed an atherogenic diet for 18 months while receiving, or not receiving (control, n= 15), the monkey equivalent to a woman's dose of 5 μg ethinyl estradiol with either 1 mg NETA daily (n= 15) or 2.5 mg MPA daily (n= 15). The left anterior descending coronary artery was occluded for 1 h and then released to allow myocardial reperfusion for 4 h. Infarct size was quantified using the histochemical stain triphenyl-tetrazolium chloride. Regional myocardial blood flow was measured by 15 μm neutron-activated microspheres, blood pressure and heart rates with a pneumatic cuff, stroke volume by echocardiography, coronary output by thermodilution and neutrophil accumulation in the myocardium using myeloperoxidase (MPO) activity.ResultsThe infarct size (area of necrosis/area at risk) was similar between the control group (21±3%) and the MPA group (29±3%)(P< 0.05) but significantly less in the NETA group (3±2%) than other groups (P< 0.05). The hemodynamic myocardial function and regional myocardial blood values were similar among groups before, during and 4 h after reperfusion (all P-values> 0.05). Similarly, there were no treatment effects on MPO activity (P> 0.05).ConclusionsNETA, but not MPA, diminished ischemia–reperfusion injury in estrogen-treated post-menopausal females. The mechanism (s) of this difference remains unclear.
