A functional relay from progesterone to vitamin D in the immune system.
A functional relay from progesterone to vitamin D in the immune system.
复制标题
DOI：
10.1089/dna.2015.2857
复制
发表时间：
2015-06
影响因子：
3.1
通讯作者：
Chang H. Kim
中科院分区：
文献类型：
--
作者：
Chang H. Kim
黄体酮是一种促进和维持怀孕的类固醇激素。维生素D(维生素D)D)，另一种类固醇激素，在其许多功能中，调节钙水平和骨骼健康。这两种荷尔蒙在调节免疫系统方面也起着重要作用。最近，我们发现T细胞中的维生素D受体(VDR)是由孕酮诱导的。这一发现将黄体酮的功能与维生素T的功能联系起来。D，并提示这两种类固醇激素相互协作，对免疫系统进行顺序和有效的调节。讨论了该法规在健康和疾病方面的潜在影响。
Progesterone is a steroid hormone that promotes and maintains pregnancy. Vitamin D (vit. D), another steroid hormone, regulates calcium levels and bone health among many of its functions. The two hormones play important roles also in regulating the immune system. Recently, we discovered that the vitamin D receptor (VDR) is induced in T cells by progesterone. This finding connects the function of progesterone to that of vit. D and suggests that the two steroid hormones cooperate with each other for sequential and effective regulation of the immune system. Potential implications of the regulation in health and disease are discussed.