Helminthosporic acid functions as an agonist for gibberellin receptor
Helminthosporic acid functions as an agonist for gibberellin receptor
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DOI：
10.1080/09168451.2017.1381018
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发表时间：
2017-01-01
影响因子：
1.6
通讯作者：
Nakajima, Masatoshi
中科院分区：
文献类型：
--
作者：
Miyazaki, Sho;Jiang, Kai;Nakajima, Masatoshi
长蠕孢酚于1963年作为天然植物生长调节剂从真菌长蠕孢霉（Helminthosporium sativum）中分离。它具有类似赤霉素的生物活性，能促进水稻第二叶鞘的生长。通过对该类化合物与一些合成类似物构效关系的研究，发现蠕虫孢酸（H-酸）具有比蠕虫孢酚更高的赤霉素样活性和化学稳定性。在本研究中，我们发现（1）H-酸不仅在水稻中而且在拟南芥中显示出类似赤霉素的活性，（2）它调节赤霉素相关基因的表达，（3）它通过与赤霉素受体（GID 1）结合诱导DELLA降解，（4）它形成GID 1-（H-酸）-DELLA复合物，以与赤霉素相同的方式抑制赤霉素信号。这项工作表明，H-酸的作用模式作为赤霉素受体的激动剂。
Helminthosporol was isolated from a fungus, Helminthosporium sativum, as a natural plant growth regulator in 1963. It showed gibberellin-like bioactivity that stimulated the growth of the second leaf sheath of rice. After studying the structure-activity relationship between the compound and some synthesized analogs, it was found that helminthosporic acid (H-acid) has higher gibberellin-like activity and chemical stability than helminthosporol. In this study, we showed that (1) H-acid displays gibberellin-like activities not only in rice but also in Arabidopsis, (2) it regulates the expression of gibberellin-related genes, (3) it induces DELLA degradation through binding with a gibberellin receptor (GID1), and (4) it forms the GID1-(H-acid)-DELLA complex to transduce the gibberellin signal in the same manner as gibberellin. This work shows that the H-acid mode of action acts as an agonist for gibberellin receptor.