A positron emission tomographic study of simple phobic symptom provocation.
A positron emission tomographic study of simple phobic symptom provocation.
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DOI：
10.1001/archpsyc.1995.03950130020003
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发表时间：
1995
影响因子：
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通讯作者：
S. Rauch;C. Savage;N. Alpert;E. Miguel;L. Baer;H. Breiter;A. Fischman;P. Manzo;Cara Moretti;M. Jenike
中科院分区：
文献类型：
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作者：
S. Rauch;C. Savage;N. Alpert;E. Miguel;L. Baer;H. Breiter;A. Fischman;P. Manzo;Cara Moretti;M. Jenike
本研究的目的是确定简单恐怖症状的介导神经解剖学。方法采用正电子发射断层扫描和氧15测定7例单纯恐怖症受试者在控制和激发状态下的正常化局部脑血流量。立体定向变换和统计参数映射技术，以确定显着激活的位置。结果统计参数图显示，与对照状态相比，症状状态下前扣带回皮质、岛叶皮质、前颞叶皮质、躯体感觉皮质、后内侧眶额皮质和丘脑的标准化局部血流量显著增加。结论：与简单恐惧症状状态相关的焦虑是由边缘结构介导的。此外，躯体感觉皮层的激活可能反映了作为恐惧症状条件的一个组成部分的触觉图像。
BACKGROUND The goal of this study was to determine the mediating neuroanatomy of simple phobic symptoms. METHODS Positron emission tomography and oxygen 15 were used to measure normalized regional cerebral blood flow in seven subjects with simple phobia during control and provoked states. Stereotactic transformation and statistical parametric mapping techniques were employed to determine the locations of significant activation. RESULTS Statistical parametric maps demonstrated significant increases in normalized regional blood flow for the symptomatic state compared with the control state in the anterior cingulate cortex, the insular cortex, the anterior temporal cortex, the somatosensory cortex, the posterior medial orbitofrontal cortex, and the thalamus. CONCLUSIONS The results suggest that anxiety associated with the simple phobic symptomatic state is mediated by paralimbic structures. Moreover, activation of somatosensory cortex may reflect tactile imagery as one component of the phobic symptomatic condition.