KCNQ1 gene polymorphisms are associated with the therapeutic efficacy of repaglinide in Chinese Type 2 diabetic patients
KCNQ1 gene polymorphisms are associated with the therapeutic efficacy of repaglinide in Chinese Type 2 diabetic patients
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DOI：
10.1111/j.1440-1681.2012.05701.x
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发表时间：
2012-05-01
影响因子：
2.9
通讯作者：
Liu, Zhao-Qian
中科院分区：
文献类型：
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作者：
Dai, Xing-Ping;Huang, Qiong;Liu, Zhao-Qian
本研究评价了KCNQ 1 rs 2237892和rs 2237895多态性对中国2型糖尿病（T2 DM）患者瑞格列奈疗效的影响。总共有367名T2 DM患者和214名对照者进行了基因分型。随机选择40例T2 DM患者接受8周瑞格列奈治疗。2型糖尿病组rs 2237892等位基因频率低于对照组（P < 0.05）。2型糖尿病患者rs 2237895 C等位基因频率高于健康对照组（P < 0.05）。携带rs 2237892危险C等位基因的糖尿病患者空腹胰岛素水平（P < 0.01）和胰岛素抵抗稳态模型评估（HOMA-IR; P < 0.01）值低于携带T等位基因的患者。携带rs 2237895危险C等位基因的糖尿病患者空腹血糖（P < 0.01）、餐后血糖（P < 0.01）和HOMA-IR值均高于携带A等位基因的糖尿病患者。在瑞格列奈治疗后，携带rs 2237892 T等位基因和rs 2237895 C等位基因的T2 DM患者更可能对瑞格列奈的PPG水平产生阳性反应（P
The present study evaluated the effects of KCNQ1 rs2237892 and rs2237895 polymorphisms on repaglinide efficacy in Chinese patients with Type 2 diabetes mellitus (T2DM). In all, 367 T2DM patients and 214 controls were genotyped. Forty of the T2DM patients were randomly selected to undergo 8 weeks repaglinide treatment. The frequency of the rs2237892 allele was lower in the T2DM patients than in the control group (P < 0.05). The frequency of the rs2237895 C allele was higher in T2DM patients than in healthy control subjects (P < 0.05). Diabetic patients with the rs2237892 risk C allele had lower fasting insulin levels (P < 0.01) and homeostasis model assessment of insulin resistance (HOMA-IR; P < 0.01) values than carriers of the T allele. Diabetic patients with the rs2237895 risk C allele had higher fasting plasma glucose (P < 0.01), postprandial plasma glucose (PPG) levels (P < 0.01) and HOMA-IR values (P < 0.01) than those with the A allele. Following repaglinide treatment, those T2DM patients with the rs2237892 T allele and rs2237895 C allele were more likely to have a positive response to repaglinide in terms of PPG levels (P