Heat Shock Proteins
Heat Shock Proteins
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DOI：
10.1006/rwgn.2001.0588
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发表时间：
2001
期刊：
影响因子：
--
通讯作者：
E. Candido
中科院分区：
文献类型：
--
作者：
E. Candido
热休克蛋白：健康和疾病的关键介质。热休克蛋白(HSP)是细胞进化过程中保守的重要分子，是细胞在环境和发育和衰老生物体组织中生存所必需的。这些蛋白质在应激中起着重要的作用，防止启动细胞程序性死亡，修复蛋白质组的损伤，使其恢复正常代谢。热休克蛋白的丧失在短期内是致命的，无论是在急性应激的情况下，还是在长期暴露在压力下的情况下。就HSP的表达而言，细胞似乎走在一条微妙的线上。如果表达低于某一水平，细胞对影响衰老和蛋白质聚集性疾病的氧化损伤变得敏感。如果HSP水平高于正常范围，就会发生炎症和致癌变化。越来越明显的是，热休克蛋白正在成为健康和疾病的多才多艺的媒介。这一系列卷的目的是研究热休克蛋白的调节和表达在病理状态下是如何改变的，以及如何通过药物和其他干预措施来补救。
Heat Shock Proteins: key mediators of Health and Disease. Heat shock proteins (HSP) are essential molecules conserved through cellular evolution required for cells to survive the stresses encountered in the environment and in the tissues of the developing and aging organism. These proteins play the essential roles in stress of preventing the initiation of programmed cell death and repairing damage to the proteome permitting resumption of normal metabolism. Loss of the HSP is lethal either in the short-term in cases of acute stress or in the long-term when exposure to stress is chronic. Cells appear to walk a fine line in terms of HSP expression. If expression falls below a certain level, cells become sensitive to oxidative damage that influences aging and protein aggregation disease. If HSP levels rise above the normal range, inflammatory and oncogenic changes occur. It is becoming clear that HSP are emerging as remarkably versatile mediators of health and disease. The aim of this series of volumes is to examine how HSP regulation and expression become altered in pathological states and how this may be remedied by pharmacological and other interventions.