Structural magnetic resonance imaging demonstrates volumetric brain abnormalities in down syndrome: Newborns to young adults.
Structural magnetic resonance imaging demonstrates volumetric brain abnormalities in down syndrome: Newborns to young adults.
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DOI：
10.1016/j.nicl.2021.102815
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Takahashi E
中科院分区：
文献类型：
--
作者：
McCann B;Levman J;Baumer N;Lam MY;Shiohama T;Cogger L;MacDonald A;Ijner P;Takahashi E
在嗅周和内嗅记忆区检测到体积异常。在关键的额外大脑区域检测到体积异常。广泛的临床验证以前唐氏综合征的结果包括。推测鼻周和内嗅参与阿尔茨海默病的病因。唐氏综合征（DS）是一种遗传性疾病，由21号染色体的额外完整或部分拷贝的存在引起，并以智力残疾为特征。我们假设对73例DS患者的磁共振成像（MRI）检查进行回顾性分析，（0至22岁），并将其与993名神经典型参与者的脑MRI检查进行比较（年龄0至32岁），将有助于更好地理解大脑差异可能解释DS的表型发育特征，并为临床上的前瞻性文献结果提供有价值的证实。从每次检查中提取绝对体积和校正为估计总颅内体积百分比（%ETIV）的体积测量值。我们的研究结果提出了新的发现，如嗅周皮质，内嗅皮质，脉络丛和布罗德曼区（BA）3a，3b和44的体积增加（%ETIV），以及楔叶，中央旁小叶，中央后回和缘上回的白色物质的体积减少（%ETIV）。我们还证实了之前文献中讨论的脑体积异常。研究结果表明，在DS中存在体积脑异常，可以在临床上用MRI检测。
Volumetric abnormalities detected in the perirhinal, entorhinal memory regions. Volumetric abnormalities detected in key additional brain regions. Extensive clinical validation of previous Down Syndrome findings included. Perirhinal and entorhinal involvement in Alzheimer’s etiology hypothesized. Down syndrome (DS) is a genetic disorder caused by the presence of an extra full or partial copy of chromosome 21 and characterized by intellectual disability. We hypothesize that performing a retrospective analysis of 73 magnetic resonance imaging (MRI) examinations of participants with DS (aged 0 to 22 years) and comparing them to a large cohort of 993 brain MRI examinations of neurotypical participants (aged 0 to 32 years), will assist in better understanding what brain differences may explain phenotypic developmental features in DS, as well as to provide valuable confirmation of prospective literature findings clinically. Measurements for both absolute volumes and volumes corrected as a percentage of estimated total intracranial volume (%ETIV) were extracted from each examination. Our results presented novel findings such as volume increases (%ETIV) in the perirhinal cortex, entorhinal cortex, choroid plexus, and Brodmann’s areas (BA) 3a, 3b, and 44, as well as volume decreases (%ETIV) in the white matter of the cuneus, the paracentral lobule, the postcentral gyrus, and the supramarginal gyrus. We also confirmed volumetric brain abnormalities previously discussed in the literature. Findings suggest the presence of volumetric brain abnormalities in DS that can be detected clinically with MRI.
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影响因子：
--
作者：
CORKIN, S;MILNER, B;RASMUSSEN, T
通讯作者：
RASMUSSEN, T
DOI：
10.1073/pnas.96.14.7705
发表时间：
1999-07-06
影响因子：
11.1
作者：
Bushnell, MC;Duncan, GH;Carrier, B
通讯作者：
Carrier, B
影响因子：
5.7
作者：
Fischl, Bruce
通讯作者：
Fischl, Bruce
影响因子：
3.6
作者：
Capio, C. M.;Mak, T. C. T.;Masters, R. S. W.
通讯作者：
Masters, R. S. W.
影响因子：
2.6
作者：
Caselli, MC;Vicari, S;Stella, G
通讯作者：
Stella, G