Superior antimetastatic effect of pemetrexed-loaded gelatinase-responsive nanoparticles in a mouse metastasis model
Superior antimetastatic effect of pemetrexed-loaded gelatinase-responsive nanoparticles in a mouse metastasis model
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负载培美曲塞的明胶酶响应纳米颗粒在小鼠转移模型中具有优异的抗转移作用
DOI：
10.1097/cad.0b013e328356dc11
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发表时间：
2012-11-01
影响因子：
2.3
通讯作者：
Liu, Baorui
中科院分区：
文献类型：
--
作者：
Lu, Nannan;Liu, Qin;Liu, Baorui
制备新型的载培美塞明胶酶敏感纳米粒作为靶向给药系统，以确定其用于恶性黑色素瘤临床治疗的潜力。负载聚乙二醇（PEG）-肽-聚（ε-己内酯）（PCL）纳米颗粒包括明胶酶切割肽和基于PEG-PCL的结构。负载培美塞的PEG-肽-PCL纳米颗粒在实验性肺转移模型中显示出最好的抗转移效果。本研究还检测了转移性肿瘤中CD 133和胸苷酸合成酶的表达。我们的研究结果表明，载培美塞明胶酶敏感纳米粒可能代表一种有效的药物输送系统，用于抑制肺转移，我们的临床前研究结果可以为恶性黑色素瘤的临床治疗提供新的途径。Anti-Cancer Drugs 23：1078-1088（C）2012 Wolters Kluwer Health垂直栏Lippincott威廉姆斯& Wilkins.
Novel pemetrexed-loaded gelatinase-responsive nanoparticles were prepared as a targeted delivery system to determine its potential for clinical therapy of malignant melanoma. The pemetrexed-loaded poly(ethylene glycol)(PEG)-peptide-poly(epsilon-caprolactone) (PCL) nanoparticles included a gelatinase-cleavage peptide and a PEG-PCL-based structure. The pemetrexed-loaded PEG-peptide-PCL nanoparticles have shown the best antimetastatic effect in experimental lung metastasis models. The expressions of CD133 and thymidylate synthetase of metastatic tumors were also evaluated in our studies. Our results showed that pemetrexed-loaded gelatinase-responsive nanoparticles may represent a potent drug delivery system for inhibiting pulmonary metastasis and our preclinical results can provide new avenues for clinical therapy of malignant melanoma. Anti-Cancer Drugs 23:1078-1088 (C) 2012 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.