Regulatory T cells in cattle and their potential role in bovine paratuberculosis
Regulatory T cells in cattle and their potential role in bovine paratuberculosis
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DOI：
10.1016/j.cimid.2012.01.004
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发表时间：
2012-05-01
影响因子：
2
通讯作者：
Colvin, Christopher J.
中科院分区：
文献类型：
--
作者：
Coussens, Paul M.;Sipkovsky, Sue;Colvin, Christopher J.
细胞内细菌鸟分枝杆菌副结核亚种 (MAP) 在野生和家养反刍动物中引起约内氏病。约翰氏病表现为一种慢性肠炎，伴有肠道组织严重炎症，其特征是巨噬细胞（MAP 的靶细胞）广泛浸润。约翰氏病的临床症状通常伴有外周 CD4+ T 细胞对 MAP 抗原反应的丧失和抗 MAP 血清 IgG 水平的升高。最近，有人提出调节性 T 细胞可能在亚临床 MAP 感染的漫长过程中发育。过去五年，牛调节性 T 细胞的定义取得了重大进展。这些研究源于这样的观察：IL-10 是由 PBMC 响应 MAP 抗原刺激而产生的，并且这种 IL-10 的中和可以增强 MAP 抗原反应性效应 T 细胞的 IFN-γ 产生。耗竭研究表明，产生 IL-10 的 MAP 响应细胞群主要是 CD4+ 和 CD25+，尽管单核细胞也已被证明能响应 MAP 产生 IL-10。此外，有关 γ δ T 细胞调节群体的证据也已开始积累。我们总结了目前关于 MAP 感染中调节性 T 细胞的想法，并提供了表明调节性 T 细胞、牛白血病病毒和 MAP 之间潜在联系的数据。 (C) 2012 Elsevier Ltd. 保留所有权利。
The intracellular bacterium Mycobacterium avium subspecies paratuberculosis (MAP) causes Johne's disease in wild and domestic ruminants. Johne's disease presents as a chronic enteritis with severe inflammation of intestinal tissues, characterized by widespread infiltration of macrophages, the target cell of MAP. Clinical signs of Johne's disease are typically accompanied by a loss of peripheral CD4+ T cell responses to MAP antigens and an increase in anti-MAP serum IgG levels. Recently, it was proposed that regulatory T cells might develop over the lengthy course of subclinical MAP infection. In the past five years, significant progress in defining bovine regulatory T cells has been made. These studies grew out of observations that IL-10 is produced by PBMCs in response to MAP antigen stimulation and that neutralization of this IL-10 could enhance IFN-gamma production from MAP-antigen reactive effector T cells. Depletion studies revealed that MAP responsive cell populations producing IL-10 were largely CD4+ and CD25+, although monocytes have also been shown to produce IL-10 in response to MAP. In addition, evidence for a regulatory population of gamma delta T cells has also begun to accumulate. We summarize current thinking regarding regulatory T cells in MAP infection and provide data suggesting a potential link between regulatory T cells, bovine leukemia virus, and MAP. (C) 2012 Elsevier Ltd. All rights reserved.