PROJECTION LINES AND THE IPSILATERAL RETINO-GENICULATE PATHWAY IN THE HOODED RAT
PROJECTION LINES AND THE IPSILATERAL RETINO-GENICULATE PATHWAY IN THE HOODED RAT
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DOI：
10.1016/0306-4522(83)90110-0
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发表时间：
1983-01-01
期刊：
影响因子：
3.3
通讯作者：
COWEY, A
中科院分区：
文献类型：
--
作者：
REESE, BE;COWEY, A
用解剖学方法研究了大鼠S外侧膝状体背侧核的组织结构，特别是双眼视野和双眼视网膜区的分布。在眼内注射辣根过氧化物酶后，在3个立体定位平面上观察同侧和对侧视网膜终末野。用顺行变性产物的银染技术研究了发自视网膜颞侧新月的投射。在离散的视网膜损伤后，有明确的证据表明，无论是同侧还是对侧，颞叶视网膜都以一种地形图的方式突出。皮质植入辣根过氧化物酶后，用细胞逆行标记的方法评估膝状回背外侧核内投射线条的方向。虽然投影线和同侧终末野在膝状背侧核中都呈吻尾状延伸，但它们的路径是倾斜的，而不是平行的。它们的交叉点似乎与视网膜共轭点在细胞核中的表示相对应。通过在初级视觉皮质的双眼或单眼代表中通过离子导入注射辣根过氧化物酶证实了这一点，同时一只眼睛接受了[~3H]Pro的注射。只有在双眼区域的皮质注射才能产生通过放射自显影标记的同侧终末野的标记投影线。大鼠S外侧膝状体背侧核不显示灵长类和猫科动物明显的细胞构筑层。即使在标记了1只眼到核团的输入后，两只眼的终末野之间仍然没有明显的板层关系。尽管没有纹层，但目前的结果表明，在大鼠的背侧外侧膝状核中，反对视网膜共轭点表示的原理与猫和猴子的相同。
The organization of the hooded rat''s dorsal lateral geniculate nucleus was studied with anatomical techniques, with paticular regard to the representation of temportal retina and the binocular field. The ipsilateral and contralateral retinal terminal fields were examined in 3 stereotaxic planes following injections of horseradish peroxidase into the eye. Projections arising from the temporal crescent of the retina were studied with Ag staining techniques for anterograde degeneration products. Following discrete retinal lesions there was clear evidence that the temporal retina projects in a topographic fashion both ipsilaterally and contralaterally. The orientation of the lines of projection in the dorsal lateral geniculate nucleus was assessed by retrograde labeling of cells after cortical implants of horseradish peroxidase. Although both the lines of projection and the ipsilateral terminal field extend rostro-caudally in the dorsal lateral geniculate nucleus, their paths are oblique rather than parallel. Their intersection appears to correspond to the representation in the nucleus of conjugate retinal points. This was confirmed by administering horseradish peroxidase by iontophoresis in either the binocular or monocular representation of the primary visual cortex, while one eye received an injection of [3H]proline. Only those cortical injections in the binocular region gave rise to labelled projection lines passing through the autoradiographically-labeled ipsilateral terminal field. The rat''s dorsal lateral geniculate nucleus displays none of the cytoarchitectural lamination which is so prominent in the primate and cat. Even after labeling the input to the nucleus from 1 eye, there is still no obvious laminar relationship between the terminal fields from the two eyes. Despite the absence of lamination, the current results suggest that the principle of apposing the representation of conjugate retinal points in the dorsal lateral geniculate nucleus is the same in the rat as in cat and monkey.