Amplitude reduction of the circadian temperature and sleep rhythms in the elderly
Amplitude reduction of the circadian temperature and sleep rhythms in the elderly
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DOI：
10.3109/07420529609012661
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发表时间：
1996-01-01
影响因子：
2.8
通讯作者：
Kupfer, DJ
中科院分区：
文献类型：
--
作者：
Carrier, J;Monk, TH;Kupfer, DJ
本研究研究了在日常生活中经历 6 小时相位提前的 St 组健康老年人的昼夜节律温度节律幅度降低与睡眠巩固参数之间的关系。 25名健康老人（15名女性，10名男性，77-91岁）住在一套时间隔离公寓里。在整个研究过程中，受试者被告知何时睡觉、起床和吃饭。实验从 5 个基线日开始，在此期间，受试者保持与其习惯性睡眠-觉醒周期相对应的日常生活，第 6 晚的觉醒时间提前 6 小时，实验剩余时间的常规保持在新的较早阶段位置不变，连续记录直肠温度，并通过多描记法记录所有睡眠发作。通过复数解调（CD）分析每个受试者的温度数据的时间序列。其中五名受试者被排除在分析之外，因为：在轮班后的日子里，由重新调节引起的方差百分比小于 55%，一名受试者被排除在外，因为他在基线期间表现出平均睡眠效率低于 55%。在其余 19 名受试者中，相移导致体温昼夜节律的平均幅度大幅下降（从 0.45 摄氏度降至 0.25 摄氏度）。在相移后的前 3 个晚上，睡眠效率下降，前半夜的清醒次数 (WFirst) 增加。没有发现后半夜（WSecond）醒来的时间有影响。温度节律幅度的变化与睡眠效率的变化（r = 0.5；p = 0.03）和 WFirst 的变化（r = -0.7；p < 0.001）显着相关。温度节律的幅度变化与WSecond之间没有相关性。这些结果表明，在老年受试者中，昼夜节律振荡器的输出幅度可能确实与睡眠巩固过程有关，但是在前半夜，而不是后半夜。
This study examined the relationship between circadian temperature rhythm amplitude reduction and sleep consolidation parameters in St group of healthy elders experiencing a 6-h phase advance in routine. Twenty-five healthy old people (15 women, 10 men, 77-91 years old) lived in a time-isolation apartment. Throughout the study, subjects were instructed when to go to bed, get up, and take meals. The experiment started with 5 baseline days during which subjects were kept to a daily routine corresponding to their habitual sleep-wake cycle, The wake time of the 6th night was phase-advanced by 6 h and the routine for the remainder of the experiment was held constant at the new earlier phase position, Rectal temperature was recorded continuously and all sleep episodes recorded polygraphically. Time series of temperature data for each subject were analyzed by complex demodulation (CD). Five of the subjects were excluded from analysis because: the percentage of variance accounted for by the remodulate was less than 55% for the postshift days and one subject was excluded because he showed an average sleep efficiency of less than 55% during baseline. In the remaining 19 subjects, the phase shift produced a large decrease of the mean amplitude of the temperature circadian rhythm (from 0.45 degrees C to 0.25 degrees C). During the first 3 nights following the phase shift, sleep efficiency was decreased and amount of wakefulness in the first half of the night (WFirst) Was increased. No effect was found for the amount of wake in the second half of the night (WSecond). The change in amplitude of the temperature rhythm was significantly correlated with change in sleep efficiency (r = 0.5; p = 0.03) and with change in WFirst (r = -0.7; p < 0.001). There was no correlation between change in the amplitude of the temperature rhythm and WSecond. These results suggest that in older subjects, amplitude of the output of the circadian oscillator might indeed be involved in the sleep consolidation process but, in the first, rather than the second half of the night.