RIP3 and AtKinesin-13A - a novel interaction linking Rho proteins of plants to microtubules.
RIP3 and AtKinesin-13A - a novel interaction linking Rho proteins of plants to microtubules.
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DOI：
10.1016/j.ejcb.2010.08.003
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发表时间：
2010-12
影响因子：
6.6
通讯作者：
Elena Mucha;Caroline Hoefle;R. Hückelhoven;A. Berken
中科院分区：
文献类型：
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作者：
Elena Mucha;Caroline Hoefle;R. Hückelhoven;A. Berken
RIP 3属于一组最近鉴定的蛋白质，被分类为ICR/RIP家族，其成员被描述为与植物的Rho蛋白（ROP）相互作用。我们的体内和体外数据表明，RIP 3是一个真正的ROP效应，特别是与活性形式的ROP相互作用。我们发现RIP 3具有不同于先前描述的RIP家族成员ICR 1/RIP 1的性质和细胞作用。我们发现RIP 3定位于微管，并与驱动蛋白-13家族成员AtKinesin-13 A相互作用，表明RIP 3在微管重组中的作用和ROP调节的极性生长中的可能功能。
RIP3 belongs to a group of recently identified proteins, classified as the ICR/RIP family whose members were described to interact with Rho proteins of plants (ROPs). Our in vivo and in vitro data demonstrate that RIP3 is a true ROP effector, interacting specifically with the active form of ROPs. We found that RIP3 has properties and cellular roles different from the previously described RIP family member ICR1/RIP1. We show that RIP3 is localized at microtubules and interacts with the kinesin-13 family member AtKinesin-13A, suggesting a role for RIP3 in microtubule reorganization and a possible function in ROP-regulated polar growth.