On the behavioral significance of head direction cells: Neural and behavioral dynamics during spatial memory tasks
On the behavioral significance of head direction cells: Neural and behavioral dynamics during spatial memory tasks
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DOI：
10.1037/0735-7044.115.2.285
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发表时间：
2001-04-01
影响因子：
1.9
通讯作者：
Taube, JS
中科院分区：
文献类型：
--
作者：
Golob, EJ;Stackman, RW;Taube, JS
目前的理论认为，大鼠在执行空间任务时使用头方向（HD）细胞反射的方向信息。通过监测前丘脑HD细胞活性并将其与受试者对2个空间记忆任务（测试参考记忆或工作记忆）的行为反应相关来评估该假设。在这两项任务中，有大量的试验中，HD细胞的首选发射方向和行为反应方向之间没有紧密耦合。此外，可以有意地改变HD单元的优选方向而不影响性能精度。另一项实验表明，影响内部的操纵。而不是外部的线索损害了参考记忆任务的表现。这些发现表明，HD细胞的活动并不总是指导受试者在这两个空间任务中的行为。
Current theories assume that rats use the directional information reflected by head direction (HD) cells when performing spatial tasks. This assumption was assessed by monitoring anterior thalamic HD cell activity and relating it to the subject's behavioral response on 2 spatial memory tasks that tested either reference memory or working memory. In both tasks, there was a significant number of trials where there was not a tight coupling between the preferred firing direction of HD cells and the direction of the behavioral response. In addition, it was possible to intentionally change the preferred direction of HD cells without affecting performance accuracy. An additional experiment showed that manipulations that affected internal. but not external, cues impaired performance on the reference memory task. These findings suggest that HD cell activity was not consistently guiding the subjects' behavior on these 2 spatial tasks.