NORADRENERGIC MODULATION OF DENDRODENDRITIC INHIBITION IN THE OLFACTORY-BULB
NORADRENERGIC MODULATION OF DENDRODENDRITIC INHIBITION IN THE OLFACTORY-BULB
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DOI：
10.1038/297227a0
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发表时间：
1982-01-01
期刊：
影响因子：
64.8
通讯作者：
NICOLL, RA
中科院分区：
文献类型：
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作者：
JAHR, CE;NICOLL, RA
用组织化学技术1-3对中枢神经系统(CNS)内含去甲肾上腺素的纤维进行了详细的研究。这一神经递质系统的一个显著特征是其神经支配的扩散模式。虽然去甲肾上腺素一般抑制神经元4-7的自发活动，但在许多系统5、8-10中，它实际上可以增强顺向兴奋反应。通过感觉中继神经元增强兴奋性传递与去甲肾上腺素系统密切参与觉醒和注意力等行为的观点一致。然而，这种增强的基础尚不清楚。提出的两个假设是兴奋性递质动作的易化5和去甲肾上腺素抑制抑制性神经元间的去抑制性动作8。嗅球非常适合研究去甲肾上腺素的细胞作用，因为神经回路相对简单。利用细胞内记录技术，我们现在已经发现去甲肾上腺素减弱了对中继神经元的抑制反馈，从而促进了它们的放电，而谷氨酸和天冬氨酸则增强了抑制反馈。
Noradrenaline containing fibres in the central nervous system (CNS) have been characterized in detail by histochemical techniques1–3. A particularly striking feature of this neurotransmitter system is its diffuse pattern of innervation. Although noradrenaline generally inhibits spontaneous activity of neurones4–7, in a number of systems5,8–10it can actually enhance orthodromic excitatory responses. Enhancement of excitatory transmission through sensory relay neurones is consistent with the view that noradrenergic systems are intimately involved in such behaviours as arousal and attention11. However, the basis for this enhancement is unclear. Two proposed hypotheses are a facilitation of excitatory transmitter action5and a disinhibitory action in which noradrenaline inhibits inhibitory inter-neurones8. The olfactory bulb is ideally suited for studying the cellular action of noradrenaline because the neuronal circuitry is relatively simple. Using intracellular recording techniques we have now found that noradrenaline attenuates the inhibitory feedback onto relay neurones, thus facilitating their firing, while glutamate and aspartate augment the inhibitory feedback.