IDENTIFICATION OF GENETICALLY HIGH-RISK INDIVIDUALS TO LUNG-CANCER BY DNA POLYMORPHISMS OF THE CYTOCHROME-P450IA1 GENE
IDENTIFICATION OF GENETICALLY HIGH-RISK INDIVIDUALS TO LUNG-CANCER BY DNA POLYMORPHISMS OF THE CYTOCHROME-P450IA1 GENE
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DOI：
10.1016/0014-5793(90)80721-t
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发表时间：
1990-04-09
期刊：
影响因子：
3.5
通讯作者：
WATANABE, J
中科院分区：
文献类型：
--
作者：
KAWAJIRI, K;NAKACHI, K;WATANABE, J
P450IA1基因限制性内切酶MspI的限制性片段长度多态(RFLP)与肺癌风险增加有很好的相关性。在健康人群中观察到优势纯合子0.49、杂合子0.40和纯合子稀有等位基因0.11的基因频率。肺癌患者中P450IA1基因纯合稀有等位基因频率约为健康人群的3倍，差异有统计学意义。这是首次从基因水平识别肺癌遗传高危个体的报道。
A good correlation was observed between enhanced lung cancer risk and restriction fragment length polymorphisms (RFLPs) of the P450IA1 gene with the restriction enzymeMspI. Genotype frequencies of 0.49 for the predominant homozygote, 0.40 for the heterozygote, and 0.11 for the homozygous rare allele were observed in a healthy population. Among lung cancer patients, the frequency of homozygous rare allele of P450IA1 gene was found to be about 3‐fold higher than that among healthy population, and this difference was statistically significant. This is the first report to identify the genetically high risk individuals to lung cancer at the gene level.