Sensitivity analysis for multiple right censoring processes: Investigating mortality in psoriatic arthritis
Sensitivity analysis for multiple right censoring processes: Investigating mortality in psoriatic arthritis
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DOI：
10.1002/sim.4117
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发表时间：
2011-02-20
影响因子：
2
通讯作者：
Siannis, Fotios
中科院分区：
文献类型：
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作者：
Siannis, Fotios
在银屑病关节炎（PsA）的死亡率研究中，删失的观察结果是由患者未能参加诊所的预约这一事实产生的。因此，有不止一种类型的右删失观测值可用。在生存分析中，删失观察的处理仍然是一个问题。虽然在许多情况下，审查的假设是合理的，但这是一个重要的假设，通常是为了方便而不是任何其他原因。在本文中，我们讨论了一个半参数模型的生存数据的分析，在感兴趣的数量的敏感性分析时，可以进行小级别的失败和删失过程之间的关联假设。模型的扩展允许存在一个以上的审查过程，其中一个可以被描述为可审查的，而另一个则不能。该模型将用于分析PsA死亡率数据，其中在不可删失的假设下可对参数进行敏感性分析。敏感性分析还将在存在两个删失过程的情况下进行，其中一个将被分类为不可删失。版权所有（C）2010约翰威利父子有限公司
In a mortality study in psoriatic arthritis (PsA), censored observations are generated from the fact that patients fail to attend their scheduled appointments at the clinic. As a result, more than one types of right-censored observations are available. In survival analysis, the treatment of censored observations remains a concern. The assumption of ignorable censoring, although in many cases justified, is an important assumption made often for convenience rather than any other reason. In this paper we discuss a semi-parametric model for the analysis of survival data, where sensitivity analysis on quantities of interest can be performed when small levels of association between the failure and the censoring processes are assumed. Extension of the model allows for the presence of more than one censoring processes, where one may be characterized as ignorable and the other not. This model will be used to analyze the PsA mortality data, where a sensitivity analysis on parameters can be done under the assumption of non-ignorable censoring. Sensitivity analysis will also be performed in the presence of two censoring processes, one of which will be classified as non-ignorable. Copyright (C) 2010 John Wiley & Sons, Ltd.