Low social support is associated with shorter leukocyte telomere length in late life: multi-ethnic study of atherosclerosis.
Low social support is associated with shorter leukocyte telomere length in late life: multi-ethnic study of atherosclerosis.
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DOI：
10.1097/psy.0b013e31828233bf
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发表时间：
2013-02
影响因子：
3.3
通讯作者：
Seeman T
中科院分区：
文献类型：
--
作者：
Carroll JE;Diez Roux AV;Fitzpatrick AL;Seeman T
主要目的是验证有限的社会支持（SS）与较短的白细胞端粒长度（LTL）有关的假设，特别是在老年人中。横断面分析对多种族动脉粥样硬化研究（MESA）的948名参与者进行，年龄45-84岁（白人18.4%，西班牙裔53.1%，非裔28.5%）。LTL采用qPCR测定，社会支持采用enrichment社会支持量表测定。在整个样本中，在调整了人口统计学（年龄、性别、种族/民族、社会经济地位）、X年龄性别、X年龄种族、健康（体重指数、糖尿病、脉压）和生活方式因素（吸烟、体育活动、饮食）后，SS与LTL不相关（p = .87），但年龄（二分类）X SS的相互作用项显著，p = .001。按年龄组分层，老年人（65 ~ 84岁）SS（评分范围：5 ~ 25）与LTL呈正相关。002), p = .007，但在调整协变量后，年轻参与者（45-64岁）不存在，p = .12。这些来自种族/民族多样化的男性和女性社区样本的结果提供了初步证据，证明低SS与65岁及以上成年人较短的LTL有关，并且与社会环境可能导致细胞衰老速率的假设一致，特别是在晚年。
The primary goal was to test the hypothesis that limited social support (SS) is related to shorter leukocyte telomere length (LTL), particularly in an older adult population. Cross-sectional analyses were performed on 948 participants at Exam 1 of the Multi-Ethnic Study of Atherosclerosis (MESA), ages 45–84 years (18.4% White, 53.1% Hispanics, and 28.5% African-American). LTL was determined using qPCR and social support was measured with the ENRICHD social support inventory. Across the entire sample, SS was not associated with LTL (p = .87) after adjusting for demographic (age, gender, race/ethnicity, socioeconomic status), age X gender, age X race, health (body mass index, diabetes, pulse pressure), and lifestyle factors (smoking, physical activity, diet), however the interaction term Age (dichotomized) X SS was significant, p = .001. Stratification by age group revealed a positive association between SS (score range: 5–25) and LTL in the older (65–84 years) B(SE) = .005(.002), p = .007, but not younger participants (45–64 years), p = .12, after adjusting for covariates. These results from a racially/ethnically diverse community sample of men and women provide initial evidence that low SS is associated with shorter LTL in adults aged 65 and older and is consistent with the hypothesis that social environment may contribute to rates of cellular aging, particularly in late life.