Scaling of gene expression with transcription-factor fugacity.
Scaling of gene expression with transcription-factor fugacity.
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DOI：
10.1103/physrevlett.113.258101
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发表时间：
2014-12-19
影响因子：
8.6
通讯作者：
Kegel WK
中科院分区：
文献类型：
--
作者：
Weinert FM;Brewster RC;Rydenfelt M;Phillips R;Kegel WK
与基因调控相关的蛋白质通常同时在多个途径之间共享。相比之下，调控生物学的模型通常假设这些途径独立发挥作用。我们展示了一个框架，用于计算基因表达的变化的相互作用的情况下，通过解耦阻遏物占据整个细胞的基因的兴趣，通过化学势的方式。相互作用的监管架构的细节包含在一个有效的浓度，因此，一个单一的缩放功能描述了从不同的监管情况下的基因表达数据的集合，并将其折叠到一个单一的主曲线。
The proteins associated with gene regulation are often shared between multiple pathways simultaneously. By way of contrast, models in regulatory biology often assume these pathways act independently. We demonstrate a framework for calculating the change in gene expression for the interacting case by decoupling repressor occupancy across the cell from the gene of interest by way of a chemical potential. The details of the interacting regulatory architecture are encompassed in an effective concentration, and thus, a single scaling function describes a collection of gene expression data from diverse regulatory situations and collapses it onto a single master curve.