Conditioned and unconditioned behavioral-cognitive effects of a dopamine antagonist in rats.
Conditioned and unconditioned behavioral-cognitive effects of a dopamine antagonist in rats.
复制标题
多巴胺拮抗剂对大鼠的条件和非条件行为认知效应。
DOI：
10.1037//0735-7044.114.6.1251
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发表时间：
2000
影响因子：
1.9
通讯作者：
Balsam,PD
中科院分区：
文献类型：
--
作者：
Ohyama,T;Horvitz,JC;Drew,MR;Gibbon,J;Malapani,C;Balsam,PD
许多药物需要多次服用才能达到治疗效果。研究人员已经确定了几种机制来解释药物作用的缓慢起效，包括药物积累和药物诱导的结构变化。这篇文章提供了一个新的机制来解释药物作用的这种变化的例子。伴随药物给药的刺激可能会引起条件反应（CR），这些CR可能是药物疗效变化的基础。具体来说，这项研究表明，多巴胺拮抗剂pimozide通过药物的直接作用改变反应速率，但通过药物给药引起的CR改变时间感知。
Many drugs need to be taken multiple times to achieve a therapeutic effect. Researchers have identified several mechanisms to account for the slow onset of drug action, including drug accumulation and structural changes induced by drugs. This article provides an example of a new mechanism to account for this change in drug action. Stimuli that accompany drug administration may come to evoke conditioned responses (CRs), and these CRs may be the basis for changes in drug efficacy. Specifically, this research shows that a dopamine antagonist, pimozide, changes response rates through the direct action of the drug but changes time perception through the CRs elicited by drug administration.