Cortical damage enhances pemoline-induced self-injurious behavior in prepubertal rats
Cortical damage enhances pemoline-induced self-injurious behavior in prepubertal rats
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DOI：
10.1016/s0091-3057(98)00152-x
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发表时间：
1999-02-01
影响因子：
3.6
通讯作者：
King, BH
中科院分区：
文献类型：
--
作者：
Cromwell, HC;Levine, MS;King, BH
自我伤害行为（SIB）是一种破坏性的特点，包括一些发育障碍，精神发育迟滞综合征。SIE的功能性神经解剖学和神经药理学尚未完全了解。大剂量全身注射匹莫林（250 mg/kg，SC）可诱导大鼠产生自咬行为（SBB）。该动物模型允许研究SIB的解剖学和药理学方面。皮质病理学在SIB患者中很常见，可能是导致该行为的基本病理因素。本实验旨在研究皮质损伤对匹莫林诱导的青春期前大鼠SBB的影响。在3-5周龄大鼠中进行双侧皮质抽吸。术后一周，进行了匹莫林激发。在损伤组和仅麻醉的对照组之间完成行为比较。结果表明，皮质损伤显著增强匹莫林诱导的SBB，沿着一些其他匹莫林诱导的刻板行为。这些结果支持了皮质损伤影响刺激诱导的自我损伤的表达的假设，并提出了这种影响的潜在机制。(C)1999 Elsevier Science Inc.
Self-injurious behavior (SIB) is a devastating characteristic of several developmental disorders including a number of mental retardation syndromes. The functional neuroanatomy and neuropharmacology of SIE is not well understood. Self-biting behavior (SBB) can be induced in rats by a high dose, systemic injection of pemoline (250 mg/kg, SC). This animal model allows for the investigation of anatomical and pharmacological aspects of SIB. Cortical pathology is a common occurrence in human disorders with SIB, and may be a fundamental pathological factor in producing the behavior. The present experiment was designed to investigate the effects of cortical damage on pemoline-induced SBB in prepubertal rats. Bilateral cortical aspirations were performed in 3-5-week-old rats. One week postsurgery, a pemoline challenge was administered. Behavioral comparisons were completed between the lesion group and an anesthetized-only control group. Results indicated that cortical damage significantly enhanced pemoline-induced SBB, along with some of the other pemoline-induced stereotypical behaviors. These results support the hypothesis that cortical damage influences the expression of stimulant-induced self-injury, and potential mechanisms for this influence are suggested. (C) 1999 Elsevier Science Inc.