In vivo amyloid imaging in autopsy-confirmed Parkinson disease with dementia
In vivo amyloid imaging in autopsy-confirmed Parkinson disease with dementia
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DOI：
10.1212/wnl.0b013e3181c7da8e
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发表时间：
2010-01-05
期刊：
影响因子：
9.9
通讯作者：
Cairns, N. J.
中科院分区：
文献类型：
--
作者：
Burack, M. A.;Hartlein, J.;Cairns, N. J.
目的：探讨[C-11]匹兹堡化合物B(PIB)体内淀粉样蛋白显像在帕金森病痴呆(PDD)中的特异性。方法：对3例死亡15个月内行PIB PET显像的PDD患者进行了详细的神经病理检查。结果：3例患者中有2例在活体PET显像上发现皮质对[C-11]-PIB的摄取增加。在尸检中，所有3个人都有丰富的皮质路易体(Braak PD阶段6)，并根据NIA-Reagan标准被归类为低概率阿尔茨海默病(AD)。2例PIB阳性患者有丰富的弥漫性Aβ斑块，但仅有稀疏的神经性斑块和中等程度的神经原纤维缠绕病理。PIB阴性的个体有罕见的弥漫性斑块，没有神经性斑块，神经纤维缠结负荷低。结论：[C-11]-匹兹堡化合物B(PIB)PET对帕金森病痴呆患者的Aβ纤维分子病理具有特异性，但不能用于阿尔茨海默病的病理诊断。[C-11]-PIB PET能够在阿尔法-突触核病的背景下专门识别纤维Aβ淀粉样蛋白，这使其成为前瞻性评估Aβ淀粉样蛋白的存在如何影响路易体疾病患者痴呆症临床病程的宝贵工具。神经病学(R)2010；74：77-84
Objective: To investigate the specificity of in vivo amyloid imaging with [C-11]-Pittsburgh Compound B (PIB) in Parkinson disease dementia (PDD).Methods: We performed detailed neuropathologic examination for 3 individuals with PDD who had PIB PET imaging within 15 months of death.Results: We observed elevated cortical uptake of [C-11]-PIB on in vivo PET imaging in 2 of the 3 cases. At autopsy, all 3 individuals had abundant cortical Lewy bodies (Braak PD stage 6), and were classified as low-probability Alzheimer disease (AD) based on NIA-Reagan criteria. The 2 PIB-positive individuals had abundant diffuse A beta plaques but only sparse neuritic plaques and intermediate neurofibrillary tangle pathology. The PIB-negative individual had rare diffuse plaques, no neuritic plaques, and low neurofibrillary tangle burden.Conclusions: [C-11]-Pittsburgh Compound B (PIB) PET is specific for fibrillar A beta molecular pathology but not for pathologic diagnosis of comorbid Alzheimer disease in individuals with Parkinson disease dementia. The ability to specifically identify fibrillar A beta amyloid in the setting of alpha-synucleinopathy makes [C-11]-PIB PET a valuable tool for prospectively evaluating how the presence of A beta amyloid influences the clinical course of dementia in patients with Lewy body disorders. Neurology (R) 2010;74:77-84