EMMA-mouse mutant resources for the international scientific community
EMMA-mouse mutant resources for the international scientific community
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DOI：
10.1093/nar/gkp799
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发表时间：
2010-01-01
影响因子：
14.9
通讯作者：
Smedley, Damian
中科院分区：
文献类型：
--
作者：
Wilkinson, Phil;Sengerova, Jitka;Smedley, Damian
实验室小鼠是研究人类疾病的首要动物模型，最近通过基因特异性诱变方法已经鉴定或产生了数千种突变体。国际敲除小鼠联盟（IKMC）的高通量策略正在产生所有蛋白质编码基因的突变体。产生敲除系涉及巨大的金钱和时间成本，因此捕获描述每个突变体的数据以及将该系存档以分发给未来的研究人员至关重要。欧洲小鼠突变体档案（EMMA）是一个领先的国际网络基础设施，用于存档和全球提供小鼠突变体品系。它与国际老鼠资源联合会（FIMRe）的其他成员合作，EMMA是欧洲的组成部分。此外，EMMA是IKMC涉及的四个存储库之一，因此目前1700个存档行的数字将显着上升。EMMA数据库收集和整理每条线路的大量数据，并通过用户友好的网站呈现。BioMart界面允许高级搜索，包括与其他资源的集成查询。G.整体其他资源可以通过访问我们的分布式注释系统服务器来显示EMMA数据。EMMA数据库访问可在http://www.emmanet.org上公开获得。
The laboratory mouse is the premier animal model for studying human disease and thousands of mutants have been identified or produced, most recently through gene-specific mutagenesis approaches. High throughput strategies by the International Knockout Mouse Consortium (IKMC) are producing mutants for all protein coding genes. Generating a knock-out line involves huge monetary and time costs so capture of both the data describing each mutant alongside archiving of the line for distribution to future researchers is critical. The European Mouse Mutant Archive (EMMA) is a leading international network infrastructure for archiving and worldwide provision of mouse mutant strains. It operates in collaboration with the other members of the Federation of International Mouse Resources (FIMRe), EMMA being the European component. Additionally EMMA is one of four repositories involved in the IKMC, and therefore the current figure of 1700 archived lines will rise markedly. The EMMA database gathers and curates extensive data on each line and presents it through a user-friendly website. A BioMart interface allows advanced searching including integrated querying with other resources e. g. Ensembl. Other resources are able to display EMMA data by accessing our Distributed Annotation System server. EMMA database access is publicly available at http://www.emmanet.org.