Insulin secretion and sensitivity in healthy adults with low vitamin D are not affected by high-dose ergocalciferol administration: a randomized controlled trial
Insulin secretion and sensitivity in healthy adults with low vitamin D are not affected by high-dose ergocalciferol administration: a randomized controlled trial
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DOI：
10.3945/ajcn.115.111682
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发表时间：
2015-08-01
影响因子：
7.1
通讯作者：
Burnett-Bowie, Sherri-Ann M.
中科院分区：
文献类型：
--
作者：
Mitchell, Deborah M.;Leder, Benjamin Z.;Burnett-Bowie, Sherri-Ann M.
背景：流行病学数据表明，低血清 25-羟基维生素 D [25(OH)D] 会增加胰岛素抵抗和 2 型糖尿病的风险。很少有干预性试验评估维生素 D 对胰岛素代谢的影响，并且已发表的结果不一致。 目的：本研究的目的是详细评估麦角钙化醇给药对总 25(OH)D 总量较低的健康人群的葡萄糖和胰岛素代谢的影响。设计：这是一项为期 12 周的双盲随机对照试验。我们招募了 90 名 18-45 岁的健康志愿者，血清 25(OH)D
Background: Epidemiologic data suggest that low serum 25-hydroxyvitamin D [25(OH)D] increases insulin resistance and the risk of type 2 diabetes. Few interventional trials have assessed the effect of vitamin D on insulin metabolism, and published results are discordant.Objective: The goal of this study was to perform a detailed assessment of the effect of ergocalciferol administration on glucose and insulin metabolism in healthy people with low total 25(OH)D-total.Design: This was a 12-wk, double-blinded, randomized controlled trial. We enrolled 90 healthy volunteers aged 18-45 y with serum 25(OH)D