Selenium and vitamin E effect on antibody production of sheep vaccinated against enzootic abortion (Chlamydia psittaci)
Selenium and vitamin E effect on antibody production of sheep vaccinated against enzootic abortion (Chlamydia psittaci)
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DOI：
10.1016/s0147-9571(99)00066-1
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发表时间：
2000-03-01
影响因子：
2
通讯作者：
Papasteriades, A
中科院分区：
文献类型：
--
作者：
Giadinis, N;Koptopoulos, G;Papasteriades, A
研究了硒和维生素E对鹦鹉热衣原体免疫绵羊产生抗体的影响。使用32只绵羊，1岁，衣原体感染血清阴性，接种肠毒血症疫苗并驱虫。对第一组动物（gSe）给予两次，间隔三周。第二组羊（gE）每只口服1 g维生素E，每周间隔6次。第三组（gSeE）动物以gSe和gE中的剂量和给药途径给予Se和vit E。第四组为对照组（gC），注射生理盐水，第一次接种与第二次注射硒同时进行。两周后再次接种。结果表明，硒单独给药可显著提高衣原体抗体反应（P < 0.05），而硒与维生素E联合给药则无显著性差异。接受维生素E（gE）的动物滴度低得多，仅高于对照组。(C)2000爱思唯尔科技有限公司版权所有。
The effect of selenium (Se) and vitamin E (vit E) on antibody production of sheep vaccinated against Chlamydia psittaci (ovis) was investigated. Thirty-two sheep, one year old, seronegative to Chlamydia infection, vaccinated against enterotoxemia and dewormed were used.Injectable sodium selenite (0.1 mg/kg b.w.) was given twice to animals of the first group (gSe), with a three week interval. The sheep of the second group (gE) received 1 g vit E each orally, six times at weekly intervals. The animals of the third group (gSeE) were given Se and vit E in doses and routes of administration as in gSe and gE. The animals of the fourth group served as controls (gC) and injected normal saline.The first vaccination was made at the time that the second Se injection was given. Revaccination was made two weeks later. The experiment lasted 29 weeks.The results indicated that Se alone led to a significant increase of Chlamydia antibody response (P < 0.05), but not when it was given in combination with vit E. Animals that received vit E (gE) had much lower titres, just above of those of the controls. (C) 2000 Elsevier Science Ltd. All rights reserved.