CHANGES IN VERTEBRAL BONE-DENSITY IN BLACK GIRLS AND WHITE GIRLS DURING CHILDHOOD AND PUBERTY
CHANGES IN VERTEBRAL BONE-DENSITY IN BLACK GIRLS AND WHITE GIRLS DURING CHILDHOOD AND PUBERTY
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DOI：
10.1056/nejm199112053252302
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发表时间：
1991-12-05
影响因子：
158.5
通讯作者：
GOODMAN, WG
中科院分区：
文献类型：
--
作者：
GILSANZ, V;ROE, TF;GOODMAN, WG
背景黑人女性骨质疏松症和椎骨骨折的患病率低于白色女性，这一发现通常归因于成年人骨量的种族差异。然而，人们对造成骨量种族差异的因素或这种差异变得明显的生命时间知之甚少。这项研究是为了描述黑人和白色女性在性发育的各个阶段椎骨骨密度的变化。我们通过定量计算机断层扫描测量了75名2 - 20岁的黑人女性受试者和75名年龄和性发育阶段相匹配的白人受试者的松质椎体骨密度。在青春期前，黑人女孩和白色女孩的椎骨骨密度没有差异。在青春期，每个种族的骨密度都有所增加，但黑人比白色受试者的骨密度增加幅度要大得多（34%比11%）。黑人和白色女性松质骨密度的显著差异发生在青春期后期的一个相对短暂的时期。与青春期性成熟相关的代谢和激素事件可能是女性骨量种族差异的重要决定因素。
Background. The prevalence of osteoporosis and the incidence of vertebral fractures are lower in black women than in white women, findings generally attributed to racial differences in adult bone mass. Little is known, however, about the factors that contribute to racial variations in bone mass or the time of life when such differences become manifest. This study was done to characterize the changes in vertebral bone density at various stages of sexual development in black and white females.Methods. We measured cancellous vertebral bone density by quantitative computed tomography in 75 black female subjects between 2 and 20 years old and 75 whites matched for age and stage of sexual development.Results. The vertebral bone density did not differ between black girls and white girls before puberty. Bone density increased during puberty in each racial group, but the magnitude of the increase from prepubertal values was substantially greater in black than in white subjects (34 percent vs. 11 percent).Conclusions. The marked difference between black and white females in cancellous vertebral bone density occurs during a relatively brief period late in puberty. Metabolic and hormonal events related to the achievement of sexual maturity during adolescence may be important determinants of racial differences in bone mass in women.