The plant-based immunomodulator curcumin as a potential candidate for the development of an adjunctive therapy for cerebral malaria
The plant-based immunomodulator curcumin as a potential candidate for the development of an adjunctive therapy for cerebral malaria
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植物性免疫调节剂姜黄素是开发脑型疟疾辅助疗法的潜在候选者
作者：
Patrice N Mimche;D. Taramelli;L. Vivas
脑型疟疾（CM）的临床表现与急性疟疾感染期间发生的主要病理生理事件密切相关，其中最重要的是寄生红细胞粘附于内皮细胞，最终导致脑毛细血管的隔离和阻塞。随之而来的血流减少导致脑缺氧、局部炎症和内皮细胞释放神经毒性分子和炎性细胞因子。免疫调节分子对这些免疫病理过程的药理学调节可能有助于这种严重并发症的治疗。CM患者使用适当的免疫调节化合物进行辅助治疗，该化合物具有甚至中等的抗疟疾活性，能够下调促炎细胞因子的过量产生和粘附分子的表达，可能会逆转细胞粘附，提高生存率并预防神经系统后遗症。目前主要的药物发现计划主要集中在新的寄生虫目标和作用机制。然而，靶向宿主的化合物的发现仍然是治疗CM的药物发现研究的一个很大程度上未探索但有吸引力的领域。这篇综述讨论了植物免疫调节剂姜黄素的特性及其作为治疗这种并发症的预防性治疗的潜力。
The clinical manifestations of cerebral malaria (CM) are well correlated with underlying major pathophysiological events occurring during an acute malaria infection, the most important of which, is the adherence of parasitized erythrocytes to endothelial cells ultimately leading to sequestration and obstruction of brain capillaries. The consequent reduction in blood flow, leads to cerebral hypoxia, localized inflammation and release of neurotoxic molecules and inflammatory cytokines by the endothelium. The pharmacological regulation of these immunopathological processes by immunomodulatory molecules may potentially benefit the management of this severe complication. Adjunctive therapy of CM patients with an appropriate immunomodulatory compound possessing even moderate anti-malarial activity with the capacity to down regulate excess production of proinflammatory cytokines and expression of adhesion molecules, could potentially reverse cytoadherence, improve survival and prevent neurological sequelae. Current major drug discovery programmes are mainly focused on novel parasite targets and mechanisms of action. However, the discovery of compounds targeting the host remains a largely unexplored but attractive area of drug discovery research for the treatment of CM. This review discusses the properties of the plant immune-modifier curcumin and its potential as an adjunctive therapy for the management of this complication.
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影响因子：
3.1
作者：
A. Tripathi;D. Sullivan;M. Stins
通讯作者：
A. Tripathi;D. Sullivan;M. Stins
罗格列酮调节对恶性疟原虫感染的先天免疫反应，并改善实验性脑型疟疾的治疗结果。
DOI：
10.1086/598222
发表时间：
2009
期刊：
The Journal of infectious diseases
影响因子：
--
作者：
Serghides,Lena;Patel,SamirN;Ayi,Kodjo;Lu,Ziyue;Gowda,DChanne;Liles,WConrad;Kain,KevinC
通讯作者：
Kain,KevinC
影响因子：
15.9
作者：
Thimmulappa, RK;Lee, H;Biswal, S
通讯作者：
Biswal, S
影响因子：
16.6
作者：
Williams, Ethan F.;Fernandez-Ruiz, Maria R.;Martins, Hugo F.
通讯作者：
Martins, Hugo F.