Environmental risk factors and Parkinson's disease: A case-control study in Taiwan
Environmental risk factors and Parkinson's disease: A case-control study in Taiwan
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DOI：
10.1212/wnl.48.6.1583
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发表时间：
1997-06-01
期刊：
影响因子：
9.9
通讯作者：
Chen, RC
中科院分区：
文献类型：
--
作者：
Liou, HH;Tsai, MC;Chen, RC
为探讨台湾地区帕金森氏症（PD）的环境危险因子，我们调查了120名PD患者和240名年龄（+/-2岁）和性别匹配的医院对照组。基于结构化的开放式问卷，我们进行了标准化的访谈，以获得暴露于环境因素的历史，包括居住地，饮用水的来源，以及各种农业化学品的环境和职业暴露。在单变量分析中，在农村环境中生活的历史，农业，除草剂/杀虫剂的使用，百草枯的使用与剂量-反应关系中PD风险增加相关。通过条件Logistic回归调整多个风险因素后，PD与以前使用除草剂/杀虫剂和百草枯之间的生物梯度仍然显着。使用百草枯和其他除草剂/杀虫剂的受试者的PD风险高于使用除百草枯以外的除草剂/杀虫剂的受试者。PD患者与对照组之间的化学品、重金属和矿物质职业暴露无显著差异。饮用井水和饮酒的时间与PD无显著相关性。吸烟与PD呈负相关。环境因素，特别是暴露于百草枯和除草剂/杀虫剂，可能在台湾PD的发展中发挥重要作用。
To explore environmental risk factors for Parkinson's disease (PD) in Taiwan, we investigated 120 patients with PD and 240 hospital control subjects matched with patients on age (+/-2 years) and sex. Based on a structured open-ended questionnaire, we carried out standardized interviews to obtain history of exposure to environmental factors, including place of residence, source of drinking water, and environmental and occupational exposures to various agricultural chemicals. In the univariate analysis, the history of living in a rural environment, farming, use of herbicides/pesticides, and use of paraquat were associated with an increased PD risk in a dose-response relationship. After adjustment for multiple risk factors through conditional logistic regression, the biological gradient between PD and previous uses of herbicides/pesticides and paraquat remained significant. The PD risk was greater among subjects who had used paraquat and other herbicides/pesticides than those who had used herbicides/pesticides other than paraquat. There were no significant differences in occupational exposures to chemicals, heavy metals, and minerals between PD patients and matched control subjects. The duration of drinking well water and alcohol consumption was not significantly associated with PD. There was an inverse relationship between cigarette smoking and PD. Environmental factors, especially exposures to paraquat and herbicides/pesticides, may play important roles in the development of PD in Taiwan.