Anxiety-induced plasma norepinephrine augmentation increases reactive oxygen species formation by monocytes in essential hypertension
Anxiety-induced plasma norepinephrine augmentation increases reactive oxygen species formation by monocytes in essential hypertension
复制标题
DOI：
10.1016/j.amjhyper.2005.10.027
复制
发表时间：
2006-06-01
影响因子：
3.2
通讯作者：
Kiriike, Nobuo
中科院分区：
文献类型：
--
作者：
Yasunari, Kenichi;Matsui, Tokuzo;Kiriike, Nobuo
工作背景：焦虑和抑郁与血压（BP）升高和心血管疾病风险之间的联系尚未确定。我们研究了这一假设，即焦虑和抑郁导致高血压患者血浆儿茶酚胺增加和单核细胞（MNC）产生活性氧（ROS）。我们还研究了BP的作用，在此effect.Methods：在协议1，横断面研究进行了146例高血压患者，以评估是否焦虑和抑郁情绪影响BP和活性氧形成的MNC通过增加血浆儿茶酚胺。在方案2中，一项为期6个月的随机对照试验，使用亚治疗剂量的α（1）-肾上腺素能受体拮抗剂多沙唑嗪（1毫克/天）与安慰剂在86例原发性高血压患者中进行，以确定是否增加活性氧形成的MNC是独立的BP。特质焦虑与血浆去甲肾上腺素呈显著正相关（r = 0.32，P
Background: An association between anxiety and depression and increased blood pressure (BP) and cardiovascular disease risk has not been firmly established. We examined the hypothesis that anxiety and depression lead to increased plasma catecholamines and to production of reactive oxygen species (ROS) by mononuclear cells (MNC) in hypertensive individuals. We also studied the role of BP in this effect.Methods: In Protocol 1, a cross-sectional study was performed in 146 hypertensive patients to evaluate whether anxiety and depression affect BP and ROS formation by MNC through increasing plasma catecholamines. In Protocol 2, a 6-month randomized controlled trial using a subtherapeutic dose of the alpha(1)-adrenergic receptor antagonist doxazosin (1 mg/day) versus placebo in 86 patients with essential hypertension was performed to determine whether the increase in ROS formation by MNC was independent of BP.Results: In Protocol 1, a significant relationship was observed between the following: trait anxiety and plasma norepinephrine (r = 0.32, P