Serum Vitamin D Deficiency as a Predictor of Incident Non-Alzheimer Dementias: A 7-Year Longitudinal Study
Serum Vitamin D Deficiency as a Predictor of Incident Non-Alzheimer Dementias: A 7-Year Longitudinal Study
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DOI：
10.1159/000334944
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发表时间：
2011-01-01
影响因子：
2.4
通讯作者：
Beauchet, O.
中科院分区：
文献类型：
--
作者：
Annweiler, C.;Rolland, Y.;Beauchet, O.
背景：维生素 D 缺乏症与痴呆和中风有关。这项纵向研究的目的是确定基线血清维生素 D 缺乏是否可以预测老年女性 7 年内非阿尔茨海默氏痴呆 (NAD) 的发病。方法：EPIDOS 图卢兹研究中的 40 名高功能老年女性（78.4 岁，76.4/82.0；中位数，第 25/75 个百分位数）根据基线维生素 D 缺乏（即血清 25-羟基维生素 D < 10 ng/ml）分为两组。在 7 年随访期结束时，符合 DSM-IV 但不符合 NINCDS-ADRDA 标准的女性被诊断为 NAD，而符合 NINCDS-ADRDA 标准的女性则被认为患有阿尔茨海默病 (AD)。基线时的轻微认知障碍、心血管危险因素和帕金森病被用作潜在的混杂因素。结果：经过 7 年的随访，6 名女性（82.8 岁，80.6/86.0）报告了 NAD。在维生素 D 缺乏的女性中观察到更多的 NAD (p = 0.023)。 AD 发病率没有组间差异 (p = 0.332)。我们发现基线维生素 D 缺乏与 NAD 发病之间存在关联（调整后的比值比 = 19.57，p = 0.042）。相反，维生素 D 缺乏与 AD 无关 (p = 0.222)。结论：基线维生素 D 缺乏症可预测老年女性 7 年内出现 NAD。版权所有 (C) 2012 S. Karger AG，巴塞尔
Background: Hypovitaminosis D has been cross-sectionally associated with dementia and stroke. The objective of this longitudinal study was to determine whether serum vitamin D deficiency at baseline could predict the onset of non-Alzheimer dementias (NAD) within 7 years among older women. Methods: Forty high-functioning older women (78.4 years, 76.4/82.0; median, 25th/75th percentile) from the EPIDOS Toulouse study were divided into two groups based on vitamin D deficiency (i.e., serum 25-hydroxyvitamin D < 10 ng/ml) at baseline. At the end of the 7-year follow-up period, women matching the DSM-IV but not the NINCDS-ADRDA criteria were diagnosed with NAD while those matching the NINCDS-ADRDA criteria were considered to have Alzheimer's disease (AD). Subtle cognitive impairments at baseline, cardiovascular risk factors and Parkinson's disease were used as potential confounders. Results: NAD was reported in 6 women (82.8 years, 80.6/86.0) after 7 years of follow-up. More NAD were observed in women with vitamin D deficiency (p = 0.023). There was no between-group difference regarding the onset of AD (p = 0.332). We found an association between vitamin D deficiency at baseline and the onset of NAD (adjusted odds ratio = 19.57, p = 0.042). Conversely, vitamin D deficiency was not associated with AD (p = 0.222). Conclusion: Baseline vitamin D deficiency predicted the onset of NAD within 7 years among older women. Copyright (C) 2012 S. Karger AG, Basel