Sixteen-week, dose-intense chemotherapy in adjuvant treatment of breast cancer.
Sixteen-week, dose-intense chemotherapy in adjuvant treatment of breast cancer.
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乳腺癌辅助治疗中的十六周剂量强化化疗。
DOI：
10.1093/jnci/82.14.1220
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发表时间：
1990
期刊：
影响因子：
--
通讯作者：
G. Hortobagyi
中科院分区：
文献类型：
--
作者：
A. Buzdar;G. Hortobagyi
正如之前报道的那样，导管插入可能是卡介苗传播的原因（5）。不良副作用虽然常见，但轻微且自限。然而，最近报告了更严重的危及生命的全身并发症。包括肉芽肿性肝炎、肺炎、全血细胞减少和BCG败血症（4，5）。在美国，有三例死亡归因于BCG滴注（6）。我们的病人在尿道内注射卡介苗后，经活检证实为粟粒性结核。建议在BCG膀胱内给药前使用3天的异烟肼预防性疗程，以防止潜在的不良副作用（4）。虽然这种方法需要进一步的评价，在我们的病人遇到的全身并发症和其他人的报告表明，需要有效的抗结核预防。
catheter insertion could be the cause of BCG dissemination, as has been previously reported (5). Adverse side effects, although common, are mild and self-limited. However, more serious life-threatening systemic complications have recently been reported. These include granulomatous hepatitis, pneumonitis, pancytopenia, and BCG sepsis (4,5). Three deaths in the United States have been attributed to BCG instillations (6). Our patient developed biopsy-documented miliary tuberculosis following intraurethral BCG instillations. A 3-day prophylactic course of isoniazid before BCG intravesical administration has been suggested to prevent potential adverse side effects (4). Although this approach needs further evaluation, the systemic complications encountered in our patient and those reported by others indicate the need for effective antituberculosis prophylaxis.