The effect of paramagnetic contrast media on T1 relaxation times in brain tumors.
The effect of paramagnetic contrast media on T1 relaxation times in brain tumors.
复制标题
顺磁造影剂对脑肿瘤 T1 弛豫时间的影响。
DOI：
10.1080/02841859809172210
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发表时间：
1998
期刊：
影响因子：
--
通讯作者：
Davis,TL
中科院分区：
文献类型：
--
作者：
Aronen,HJ;Niemi,P;Kwong,KK;Pardo,FS;Davis,TL
目的：材料和方法：对17例已知或疑似脑肿瘤患者进行了10种不同反转时间的回波平面反转恢复成像序列研究。Gd螯合物的双重注射5例患者给予0.1 mmol/kg+0.2 mmol/kg剂量，12例患者单次给予0.2 mmol/kg剂量。在0.2 mmol/kg剂量后，灰质中的T1从1121 ± 130 ms降至987 ± 103 ms白色物质从666 ± 29 ms增加到646 ± 27 ms（p <0.001）。肿瘤T1从1515 ± 319 ms缩短至717 ± 383 ms。在0.1 mmol/kg剂量（n=5）后，肿瘤T1从1116 ± 261 ms缩短至793 ± 202 ms，在额外0.2 mmol/kg剂量后，肿瘤T1进一步缩短至526 ± 141 ms。对比后T1弛豫时间在肿瘤表现出相当大的变化，并保持，平均而言，相对较长的相比，白色的问题。在决定哪种脉冲序列、成像参数和造影剂剂量最适合脑肿瘤成像时，应考虑到这一点
Purpose: to study T1 relaxation times in brain tumors before and after paramagnetic contrast medium injectionMaterial and Methods: Seventeen patients with a known or suspected brain tumor were studied with an echo planar inversion recovery imaging sequence using 10 different inversion times. Double injections of Gd chelate (0.1 mmol/kg+0.2 mmol/kg) were administered in 5 patients, and a single 0.2-mmol/kg dose in 12 patientsResults: After the 0.2-mmol/kg dose, T1 decreased from 1121 ± 130 ms to 987 ± 103 ms in gray matter (pĩ0.001), and from 666 ± 29 ms to 646 ± 27 ms in white matter (pĩ0.001). Tumor T1 shortened from 1515 ± 319 ms to 717 ± 383 ms. After the 0.1-mmol/kg dose (n=5), tumor T1 decreased from 1116 ± 261 ms to 793 ± 202 ms and after the additional 0.2-mmol/kg dose it decreased further to 526 ± 141 msConclusion: Postcontrast T1 relaxation times in tumors showed considerable variation and remained, on average, relatively long compared to white matter. This should be taken into account when deciding which pulse sequences, imaging parameters, and contrast agent doses are optimal for brain tumor imaging