Repeated premotor rTMS leads to cumulative plastic changes of motor cortex excitability in humans
Repeated premotor rTMS leads to cumulative plastic changes of motor cortex excitability in humans
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DOI：
10.1016/s1053-8119(03)00310-0
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发表时间：
2003-09-01
期刊：
影响因子：
5.7
通讯作者：
Münchau, A
中科院分区：
文献类型：
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作者：
Bäumer, T;Lange, R;Münchau, A
我们探讨了两次运动前1hz rTMS对健康人运动皮质兴奋性的影响。在实验1中，11名健康的右撇子志愿者连续2天在左侧运动前皮层接受20分钟的运动阈值1 Hz rTMS训练。分别在每次rTMS后的基线、立即、30、60、120分钟和24小时测定左运动皮层兴奋性。在刺激间隔（ISI） 3- 7,10和15ms时，我们测量了运动阈值、运动诱发电位振幅、沉默期和成对脉冲兴奋性。在实验2中，5名志愿者在第1天和第7天接受了两组相同的rTMS训练。测量在第1天（第一次rTMS列车）、第2天和第7天（第二次rTMS列车）进行。在实验1中，在第1天rTMS持续不到30分钟后，在ISI为7 ms时，配对脉冲促进选择性增加。这种效果在第2天的rTMS后也存在。在实验2中，rTMS在第1天和第7天诱导了相同的额外促进作用，但在第2天没有。第1天和第7天均持续不到30分钟。我们得出结论：1 Hz运动前rTMS在24小时内可引起运动皮质内禀兴奋性的累积塑性变化，而在1周后不会发生，这表明记忆的形成是在第一次rTMS训练持续1天以上但不到1周后形成的。(C) 2003 Elsevier Inc.版权所有。
We explored the aftereffects of two premotor 1 Hz rTMS sessions on motor cortex excitability in healthy humans. In experiment 1, 11 healthy right-handed volunteers received 20-min submotor threshold I Hz rTMS trains over the left premotor cortex on 2 consecutive days. Left motor cortex excitability was determined at baseline, immediately after, 30, 60, 120 min, and 24 h after each rTMS session. We measured motor thresholds, amplitudes of motor-evoked potentials, silent periods, and paired-pulse excitability at interstimulus intervals (ISI) of 3-7, 10, and 15 ms. In experiment 2, 5 volunteers received two identical rTMS trains on Days 1 and 7. Measurements were carried out on Day I (first rTMS train), Day 2, and Day 7 (second rTMS train). In experiment I there was a selective increase of paired pulse facilitation at an ISI of 7 ms after rTMS lasting for less than 30 min on Day 1. This effect was also present after rTMS on Day 2. However, it persisted for at least 2 h. In experiment 2 the same extra facilitation was induced by rTMS on Days I and 7 but not on Day 2. It lasted for less than 30 min on both Day I and Day 7. We conclude that I Hz premotor rTMS leads to cumulative plastic changes of intrinsic motor cortex excitability when repeated within 24 h but not after 1 week, implying the formation of memory after the first rTMS train lasting more than a day but less than a week. (C) 2003 Elsevier Inc. All rights reserved.