The complete nucleotide sequence of enterovirus type 70: relationships with other members of the picornaviridae.
The complete nucleotide sequence of enterovirus type 70: relationships with other members of the picornaviridae.
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70 型肠道病毒的完整核苷酸序列：与小核糖核酸病毒科其他成员的关系。
DOI：
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发表时间：
1990
影响因子：
3.8
通讯作者：
J. Almond
中科院分区：
文献类型：
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作者：
M. Ryan;O. Jenkins;P. Hughes;A. Brown;N. Knowles;D. Booth;P. Minor;J. Almond
70 型肠道病毒 (EV70) 是急性出血性结膜炎的病原体，也可能引起与脊髓灰质炎非常相似的罕见神经并发症。 EV70 基因组的完整核苷酸序列已从大肠杆菌中克隆的 cDNA 中确定。该基因组由 726 个核苷酸 (nt) 的 5' 非编码区、6582 nt 的长开放阅读框和位于 Poly(A) 区域之前的 82 nt 的 3' 非编码区组成。将多蛋白的核苷酸序列和预测的氨基酸序列与已发表的其他肠道病毒的序列进行比较，揭示出足够高的相似性以预测抗原区域和多蛋白切割位点。 EV70 的 P1 区域与肠道病毒和鼻病毒相似，而 P2 和 P3 区域与柯萨奇 B 型病毒和猪水泡病病毒的关系比其他肠道病毒或鼻病毒更密切。
Enterovirus type 70 (EV70) is the causative agent of acute haemorrhagic conjunctivitis and may also give rise to a rare neurological complication closely resembling poliomyelitis. The complete nucleotide sequence of the genome of EV70 has been determined from cDNA cloned in Escherichia coli. The genome consists of a 5' non-coding region of 726 nucleotides (nt), a long open reading frame of 6582 nt and a 3' non-coding region of 82 nt prior to the poly(A) tract. Comparison of the nucleotide sequence and the predicted amino acid sequence of the polyprotein with those published for other enteroviruses reveals sufficiently high similarity to predict antigenic regions and polyprotein cleavage sites. The P1 region of EV70 is as similar to those of the entero- as to those of the rhinoviruses, whereas the P2 and P3 regions are more closely related to the coxsackie B and swine vesicular disease viruses than other entero- or rhinoviruses.
影响因子：
56.9
作者：
HOGLE, JM;CHOW, M;FILMAN, DJ
通讯作者：
FILMAN, DJ