Feedback inhibition of osteoclastogenesis during inflammation by IL-10, M-CSF receptor shedding, and induction of IRF8.
Feedback inhibition of osteoclastogenesis during inflammation by IL-10, M-CSF receptor shedding, and induction of IRF8.
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DOI：
10.1111/j.1749-6632.2011.06217.x
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发表时间：
2011-11
影响因子：
5.2
通讯作者：
Takami M
中科院分区：
文献类型：
--
作者：
Ivashkiv LB;Zhao B;Park-Min KH;Takami M
炎症在类风湿性关节炎和牙周炎等疾病中的过度骨丢失中起着关键作用。免疫学中的一个重要范式是，炎症因子激活反馈抑制机制，以抑制炎症并限制相关的组织损伤。我们假设炎症因子将激活类似的反馈机制来抑制炎症环境中的骨丢失。我们已经确定了三种抑制破骨细胞生成的机制，这些机制由炎症因子如Toll样受体配体和细胞因子诱导：下调共刺激分子如TREM-2的表达；诱导M-CSF受体c-FMS的脱落从而使其失活，导致RANK转录降低；以及诱导转录抑制因子如干扰素调节因子8。这些机制可能以互补和协同的方式在炎症环境下微调破骨细胞形成的程度，它们的增强可能是抑制骨吸收的另一种治疗方法。
Inflammation plays a key role in excessive bone loss in conditions such as rheumatoid arthritis and periodontitis. An important paradigm in immunology is that inflammatory factors activate feedback inhibition mechanisms to restrain inflammation and limit associated tissue damage. We hypothesized that inflammatory factors would activate similar feedback mechanisms to restrain bone loss in inflammatory settings. We have identified three mechanisms that inhibit osteoclastogenesis and are induced by inflammatory factors, such as toll-like receptor ligands and cytokines: downregulation of expression of costimulatory molecules such as TREM-2; induction of shedding and thereby inactivation of the M-CSF receptor c-Fms, leading to decreased RANK transcription; and induction of transcriptional repressors such as interferon regulatory factor 8. It is likely that these mechanisms work in a complementary and cooperative manner to fine tune the extent of osteoclastogenesis in inflammatory settings, and their augmentation may represent an alternative therapeutic approach to suppress bone resorption.
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影响因子：
--
作者：
Kalliolias, George D.;Zhao, Baohong;Triantafyllopoulou, Antigoni;Park-Min, Kyung-Hyun;Ivashkiv, Lionel B.
通讯作者：
Ivashkiv, Lionel B.
DOI：
10.4049/jimmunol.0804165
发表时间：
2009-08-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Park-Min KH;Ji JD;Antoniv T;Reid AC;Silver RB;Humphrey MB;Nakamura M;Ivashkiv LB
通讯作者：
Ivashkiv LB
影响因子：
4.8
作者：
Liu, Jianzhong;Wang, Shunqing;Feng, Xu
通讯作者：
Feng, Xu
影响因子：
6.2
作者：
Li, P;Schwarz, EM;Xing, LP
通讯作者：
Xing, LP
影响因子：
15.3
作者：
Kim, N;Kadono, Y;Choi, Y
通讯作者：
Choi, Y