Functional Connectivity from the Amygdala to the Hippocampus Grows Stronger after Stress
Functional Connectivity from the Amygdala to the Hippocampus Grows Stronger after Stress
复制标题
DOI：
10.1523/jneurosci.0638-13.2013
复制
发表时间：
2013-04-24
影响因子：
5.3
通讯作者：
Chattarji, Sumantra
中科院分区：
文献类型：
--
作者：
Ghosh, Supriya;Laxmi, T. Rao;Chattarji, Sumantra
应激对杏仁核的细胞和分子效应与海马体中的效应相比有着显著的不同。以前的研究结果应力诱导的可塑性主要是基于在个别地区的尸检分析。然而，很少有人知道压力如何影响动态变化和两个区域之间的神经元活动的相互作用。因此，我们同时监测在体内活动的神经元群体位于海马区CA1和CA3和杏仁核（LA）在大鼠慢性制动应力期间和之后。海马神经元诱发电位（AEPs）的幅值仅在单次应激2h后出现一过性升高，而在重复应激10d后则无明显变化。相反，急性和慢性应激均导致LA的AEP持续增加。慢性应激也引起了持续增加的LA，但减少在海马中的γ和β频率的诱发功率。此外，β和γ同步性减少之间的区域CA1和CA3，但增强之间的LA和海马慢性应激后。格兰杰因果关系谱显示了一个强大的方向性影响，从LA到CA 1区，持续整个，甚至10天后慢性应激。而海马CA3区到CA1区的定向耦合在慢性应激结束时减弱。因此，我们的研究结果表明，在慢性压力期间，甚至在慢性压力之后，杏仁核活动对海马体的主导地位不断增加，这可能有助于增强情绪症状，以及与压力相关的精神疾病中出现的认知功能受损。
The cellular and molecular effects of stress on the amygdala are strikingly different compared with those in the hippocampus. Previous findings on stress-induced plasticity were based primarily on postmortem analysis within individual areas. However, little is known about how stress affects dynamic changes and interactions in neuronal activity between the two areas. Hence, we simultaneously monitored in vivo activity of neuronal populations located in hippocampal areas CA1 and CA3 and the lateral amygdala (LA) in rats during and after chronic immobilization stress. The amplitude of auditory-evoked potentials (AEPs) in the hippocampus increased transiently only after a single 2 h stress but not when it was repeated for 10 d. In contrast, both acute and chronic stress caused a persistent increase in AEPs in the LA. Chronic stress also elicited a sustained increase in the LA but a decrease in the hippocampus in the evoked power of gamma and beta frequencies. Moreover, beta and gamma synchrony was reduced between areas CA1 and CA3 but enhanced between the LA and hippocampus after chronic stress. Granger causality spectra revealed a strong directional influence from the LA to area CA1 that persisted throughout and even 10 d after chronic stress. However, directional coupling from hippocampal area CA3 to CA1 became weaker at the end of chronic stress. Thus, our findings suggest that the growing dominance of amygdalar activity over the hippocampus during and even after chronic stress may contribute to the enhanced emotional symptoms, alongside impaired cognitive function, seen in stress-related psychiatric disorders.