Assessment of Early Response to Lung Cancer Chemotherapy by Semiquantitative Analysis of Dynamic Contrast-Enhanced MRI.
Assessment of Early Response to Lung Cancer Chemotherapy by Semiquantitative Analysis of Dynamic Contrast-Enhanced MRI.
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DOI：
10.1155/2022/2669281
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发表时间：
2022
期刊：
影响因子：
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通讯作者：
Xu, Jianxing
中科院分区：
文献类型：
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作者：
Zhu, Jiang;Yun, Jian;Wang, Kaixiang;Liu, Liangqing;Zheng, Jiangang;Mei, Li;Xu, Jianxing
应用动态增强磁共振成像（DCE）半定量分析评价肺癌患者的早期化疗反应。 对22例接受化疗的肺癌患者在两个时间点进行DCE-MRI检查：开始治疗前和治疗一周后。采用DCE-MRI采集图像数据，计算阳性增强积分（PEI）、信号增强比（SER）、最大增强斜率（MSI）、达峰时间（TTP）等半定量参数。化疗后，用Mann-Whitney U检验比较应答者和无应答者之间的参数和相关变化。配对样本的学生t检验用于评估治疗前和治疗后图像之间的时间变化。 根据肿瘤缓解评价，将患者分类为13例缓解者和9例无缓解者。化疗后，应答者PEI、SER、MSI较化疗前明显升高（P < 0.05），TTP无明显下降（P > 0.05）。9例无效者PEI、SER、MSI、TTP与治疗前比较无显著性差异（P > 0.05）。应答组PEI较无应答组显著增高（P < 0.05），而SER、MSI、TTP差异无显著性（P > 0.05）。 DCE-MRI半定量分析可为肺癌患者早期化疗反应的评估提供一种可靠的无创性方法。
To evaluate the early chemotherapy response in patients with lung cancer using semiquantitative analysis of dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI). Twenty-two patients with lung cancer treated with chemotherapy were subjected to DCE-MRI at two time points: before starting treatment and after one week of therapy. The image data were collected by DCE-MRI, and the semiquantitative parameters including positive enhancement integral (PEI), signal enhancement ratio (SER), maximum slope of increase (MSI), and time to peak (TTP) were calculated. After chemotherapy, the parameters and relevant variations between the responders and nonresponders were compared with Mann–Whitney U tests. Student's t-test for paired samples was used to evaluate the temporal changes between pre- and posttreatment images. The patients were categorized as 13 responders and 9 nonresponders based on the tumor response evaluation. After chemotherapy, the PEI, SER, and MSI were significantly increased in responders compared with the pretreatment values (P < 0.05), while no obvious decrease in TTP was observed (P > 0.05). However, 9 nonresponders showed no significant changes in PEI, SER, MSI, and TTP values, as compared with those of pretreatment (P > 0.05). Moreover, the increase of PEI was more dramatically in responders than in nonresponders (P < 0.05), but no significantly differences were observed in SER, MSI, and TTP (P > 0.05). Semiquantitative analysis of DCE-MRI could provide a reliable noninvasive method for assessing early chemotherapy response in lung cancer patients.