Measuring the elastic modulus of small tissue samples
Measuring the elastic modulus of small tissue samples
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DOI：
10.1177/016173469802000102
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发表时间：
1998-01-01
影响因子：
2.3
通讯作者：
O'Donnell, M
中科院分区：
文献类型：
--
作者：
Erkamp, RQ;Wiggins, P;O'Donnell, M
组织的弹性模量（杨氏模量）的独立测量是将弹性成像转变为临床工具的必要步骤。研制了一种能够测量小组织样品弹性模量的系统。该系统能够承受生物组织的限制，例如有限的样本尺寸小于或等于1.5 cm（3）以及样本几何形状的缺陷。在对组织样本施加已知变形的同时，测量合力。然后将这些测量值转换为弹性模量，其中转换使用具有已知杨氏模量的增塑溶胶样品的系统的先前校准。从10到80千帕，覆盖了广泛的组织模量值的准确测量已经获得。此外，该系统的性能进行了进一步研究，使用有限元分析。最后，初步的弹性测量犬肾脏样品的介绍和讨论。(C)1998 Dynamedia，Inc.
Independent measurements of the elastic modulus (Young' s modulus) of tissue are a necessary step in turning elasticity imaging into a clinical tool. A system capable of measuring the elastic modulus of small tissue samples was developed. The system tolerates the constraints of biological tissue, such as limited sample size less than or equal to 1.5 cm(3)) and imperfections in sample geometry.A known deformation is applied to the tissue sample while simultaneously measuring the resulting force. These measurements are then converted to an elastic modulus, where the conversion uses prior calibration of the system with plastisol samples of known Young's modulus. Accurate measurements have been obtained from 10 to 80 kPa, covering a wide range of tissue modulus values. In addition, the performance of the system was further investigated using finite element analysis. Finally, preliminary elasticity measurements on canine kidney samples are presented and discussed. (C) 1998 Dynamedia, Inc.