Making Aggregation-Induced Emission Luminogen More Valuable by Gold: Enhancing Anticancer Efficacy by Suppressing Thioredoxin Reductase Activity.
Making Aggregation-Induced Emission Luminogen More Valuable by Gold: Enhancing Anticancer Efficacy by Suppressing Thioredoxin Reductase Activity.
复制标题
DOI：
10.1021/acsnano.1c02882
复制
发表时间：
2021-05
期刊：
影响因子：
17.1
通讯作者：
Hang Zou;Jing Zhang;Changmeng Wu;Benzhao He;Yubing Hu;H. Sung;R. K. Kwok;J. Lam;Lei Zheng
中科院分区：
文献类型：
--
作者：
Hang Zou;Jing Zhang;Changmeng Wu;Benzhao He;Yubing Hu;H. Sung;R. K. Kwok;J. Lam;Lei Zheng
金配合物由于其固有的抗氧化硫氧还蛋白还原酶（TrxR）活性而被认为是潜在的抗肿瘤药物。本文设计并合成了一种高效聚集诱导发光发光体（AIEgen）TBP-Au，该发光体通过将抗癌活性的Au（I）基团与具有AIE活性的光敏剂（TBP）相结合，同时考虑了活性氧（ROS）的产生和消耗途径，以提高其抗癌活性。研究表明，TBP-Au具有良好的AIE特性，可实现肿瘤组织的上级双光子荧光成像，具有高分辨率和深穿透性，并可在活体动物中实现长时间成像。此外，引入特殊的Au（I）部分可以调节细胞器的特异性并有效地促进ROS决定的光动力疗法（PDT）。更令人印象深刻的是，TBP-Au可以通过PDT的预先设想的协同方法和TrxR的有效抑制，在光照射下有效地消除癌细胞，这表明TBP-Au在精确的癌症治疗诊断方面具有巨大的潜力。
Gold complexes have been recognized as potential anticancer agents against various kinds of diseases due to their inherent suppressions of antioxidant thioredoxin reductase (TrxR) activity. Herein, a powerful aggregation-induced emission luminogen (AIEgen), TBP-Au, was designed and synthesized by integrating an anticancer Au(I) moiety with an AIE-active photosensitizer (TBP), in which both the production and consumption routes of reactive oxygen species (ROS) were elaborately considered simultaneously to boost the anticancer efficacy. It has been demonstrated that TBP-Au could realize superior two-photon fluorescence imaging in tumor tissues with high resolution and deep penetration as well as long-term imaging in live animals due to its AIE property. In addition, the introduction of a special Au(I) moiety could tune the organelle specificity and efficiently facilitate the ROS-determined photodynamic therapy (PDT). More impressively, TBP-Au could efficiently eliminate cancer cells under light irradiation through the preconceived synergetic approaches from the PDT and the effective suppression of TrxR, demonstrating that TBP-Au holds great potential for precise cancer theranostics.