Health status in 1040 adults with disorders of sex development (DSD): a European multicenter study
Health status in 1040 adults with disorders of sex development (DSD): a European multicenter study
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DOI：
10.1530/ec-18-0031
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发表时间：
2018-03-01
影响因子：
2.9
通讯作者：
Kohler, Birgit
中科院分区：
文献类型：
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作者：
Falhammar, Henrik;Claahsen-van der Grinten, Hedi;Kohler, Birgit
目的：性发育障碍（DSD）成人的健康状况的知识是稀缺的。设计和方法：在14个欧洲三级中心的横断面观察性研究招募了1040名参与者（717名女性，311名男性，12人）与DSD。平均年龄为32.4 ± 13.6岁（范围16-75岁）。队列分为：Turner（n = 301）、Klinefelter（n = 224）、XY-DSD（n = 222）、XX-DSD（不包括先天性肾上腺增生（CAH）和46，XX男性）（n = 21）、46，XX-CAH（n = 226）和45，X/46，XY（n = 45）。结果：在DSD中，91.4%的人报告一般健康状况良好，只有8.6%的人报告（非常）不良的一般健康状况（对照组94.0%和6.0%，P
Objective: The knowledge about health status in adults with disorder of sex development (DSD) is scarce.Design and methods: A cross-sectional observational study in 14 European tertiary centers recruited 1040 participants (717 females, 311 males, 12 others) with DSD. Mean age was 32.4 +/- 13.6 year (range 16-75). The cohort was divided into: Turner (n = 301), Klinefelter (n = 224), XY-DSD (n = 222), XX-DSD (excluding congenital adrenal hyperplasia (CAH) and 46,XX males) (n = 21), 46,XX-CAH (n = 226) and 45,X/46,XY (n = 45). Perceived and objective health statuses were measured and compared to European control data.Results: In DSD, fair to very good general health was reported by 91.4% and only 8.6% reported (very) bad general health (controls 94.0% and 6.0%, P