Magnetic Resonance Imaging-Transrectal Ultrasound Guided Fusion Biopsy to Detect Progression in Patients with Existing Lesions on Active Surveillance for Low and Intermediate Risk Prostate Cancer.
Magnetic Resonance Imaging-Transrectal Ultrasound Guided Fusion Biopsy to Detect Progression in Patients with Existing Lesions on Active Surveillance for Low and Intermediate Risk Prostate Cancer.
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DOI：
10.1016/j.juro.2016.08.109
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发表时间：
2017-03
期刊：
影响因子：
--
通讯作者：
Pinto PA
中科院分区：
文献类型：
--
作者：
Frye TP;George AK;Kilchevsky A;Maruf M;Siddiqui MM;Kongnyuy M;Muthigi A;Han H;Parnes HL;Merino M;Choyke PL;Turkbey B;Wood B;Pinto PA
积极监测是低风险前列腺癌男性的既定选择。与系统性12芯活检相比，多参数磁共振成像与磁共振成像-经直肠超声融合引导活检可以更好地识别患者进行主动监测，因为其改善了风险分层。据我们所知，多参数磁共振成像在主动监测可见病变的男性中的表现尚不清楚。我们评估了多参数磁共振成像和磁共振成像-经直肠超声融合引导活检对主动监测男性的监测作用。这项回顾性综述纳入了2007年至2015年接受主动监测的前列腺癌男性，其中通过多参数磁共振成像和融合引导活检监测磁共振成像可见病变。进展定义为ISUP（国际泌尿病理学会）1 - 2级组和ISUP 2 - 3级组。在p ≤0.05时认为具有显著性。共有166例接受主动监测并进行2次或2次以上融合引导活检的患者被纳入分析。平均随访时间为25.5个月。29.5%的患者出现病理进展。单独靶向活检确定了44.9%的进展患者，而单独系统性12芯活检确定了30.6%的进展患者（p = 0.03）。与系统性12芯活检相比，融合引导活检在监测活检中检测到的病理进展病例多26%。多参数磁共振成像的进展是监测活检病理进展的唯一预测因素（p = 0.013）。在整个队列中，多参数磁共振成像进展检测病理进展的阴性预测值为81%，阳性预测值为35%，敏感性为77.6%，特异性为40.5%。多参数磁共振成像进展预测病理进展的风险。多参数磁共振成像结果稳定的患者进展率较低。与系统性12芯活检相比，在主动监测中进行融合引导活检几乎使我们对病理进展的检测增加了一倍。
Active surveillance is an established option for men with low risk prostate cancer. Multiparametric magnetic resonance imaging with magnetic resonance imaging-transrectal ultrasound fusion guided biopsy may better identify patients for active surveillance compared to systematic 12-core biopsy due to improved risk stratification. To our knowledge the performance of multiparametric magnetic resonance imaging in following men on active surveillance with visible lesions is unknown. We evaluated multiparametric magnetic resonance imaging and magnetic resonance imaging-transrectal ultrasound fusion guided biopsy to monitor men on active surveillance. This retrospective review included men from 2007 to 2015 with prostate cancer on active surveillance in whom magnetic resonance imaging visible lesions were monitored by multiparametric magnetic resonance imaging and fusion guided biopsy. Progression was defined by ISUP (International Society of Urological Pathology) grade group 1 to 2 and ISUP grade group 2 to 3. Significance was considered at p ≤0.05. A total of 166 patients on active surveillance with 2 or more fusion guided biopsies were included in analysis. Mean followup was 25.5 months. Of the patients 29.5% had pathological progression. Targeted biopsy alone identified 44.9% of patients who progressed compared to 30.6% identified by systematic 12-core biopsy alone (p = 0.03). Fusion guided biopsy detected 26% more cases of pathological progression on surveillance biopsy compared to systematic 12-core biopsy. Progression on multiparametric magnetic resonance imaging was the sole predictor of pathological progression at surveillance biopsy (p = 0.013). Multiparametric magnetic resonance imaging progression in the entire cohort had 81% negative predictive value, 35% positive predictive value, 77.6% sensitivity and 40.5% specificity in detecting pathological progression. Multiparametric magnetic resonance imaging progression predicts the risk of pathological progression. Patients with stable multiparametric magnetic resonance imaging findings have a low rate of progression. Incorporating fusion guided biopsy in active surveillance nearly doubled our detection of pathological progression compared to systematic 12-core biopsy.
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影响因子：
6.2
作者：
Stamatakis L;Siddiqui MM;Nix JW;Logan J;Rais-Bahrami S;Walton-Diaz A;Hoang AN;Vourganti S;Truong H;Shuch B;Parnes HL;Turkbey B;Choyke PL;Wood BJ;Simon RM;Pinto PA
通讯作者：
Pinto PA
MR/超声融合引导的活检与超声引导活检的比较，以诊断前列腺癌。
DOI：
10.1001/jama.2014.17942
发表时间：
2015-01-27
期刊：
JAMA
影响因子：
--
作者：
Siddiqui MM;Rais-Bahrami S;Turkbey B;George AK;Rothwax J;Shakir N;Okoro C;Raskolnikov D;Parnes HL;Linehan WM;Merino MJ;Simon RM;Choyke PL;Wood BJ;Pinto PA
通讯作者：
Pinto PA
DOI：
10.1016/j.juro.2012.06.011
发表时间：
2012-10
期刊：
The Journal of urology
影响因子：
--
作者：
Turkbey B;Mani H;Aras O;Rastinehad AR;Shah V;Bernardo M;Pohida T;Daar D;Benjamin C;McKinney YL;Linehan WM;Wood BJ;Merino MJ;Choyke PL;Pinto PA
通讯作者：
Pinto PA
影响因子：
23.4
作者：
Cohen, Michael S.;Hanley, Robert S.;Libertino, John A.
通讯作者：
Libertino, John A.
影响因子：
23.4
作者：
Siddiqui MM;Rais-Bahrami S;Truong H;Stamatakis L;Vourganti S;Nix J;Hoang AN;Walton-Diaz A;Shuch B;Weintraub M;Kruecker J;Amalou H;Turkbey B;Merino MJ;Choyke PL;Wood BJ;Pinto PA
通讯作者：
Pinto PA