THE MACROPHAGE
THE MACROPHAGE
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DOI：
10.1002/bies.950171111
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发表时间：
1995-11-01
期刊：
影响因子：
4
通讯作者：
GORDON, S
中科院分区：
文献类型：
--
作者：
GORDON, S
巨噬细胞在宿主发育和生理，以及许多感染性、免疫和退行性疾病的发病过程中起着重要作用。它在不同组织中表现出明显的表型异质性，反映了与其他细胞类型的局部相互作用，并通过各种质膜和分泌分子来维持宿主的稳态。从体内分离后，它继续表现出细胞组织和功能的特殊和一般特征，这使得在细胞培养中研究它是一件令人愉快的事情。
The macrophage plays an important role in host development and physiology, and in pathogenesis of many infectious, immunologic and degenerative disease processes. It displays marked heterogeneity of phenotype in different tissues, reflecting local interactions with other cell types, and contributes to host homeostasis through a varied repertoire of plasma membrane and secretory molecules. Upon isolation from the body it continues to express special, as well as general, features of cellular organisation and function, which make it a delight to study in cell culture.