Evidence that acute serotonergic activation potentiates the locomotor-stimulating effects of corticotropin-releasing hormone in juvenile chinook salmon (Oncorhynchus tshawytscha)
Evidence that acute serotonergic activation potentiates the locomotor-stimulating effects of corticotropin-releasing hormone in juvenile chinook salmon (Oncorhynchus tshawytscha)
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DOI：
10.1016/s0018-506x(02)00027-2
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发表时间：
2003-01-01
影响因子：
3.5
通讯作者：
Schreck, CB
中科院分区：
文献类型：
--
作者：
Clements, S;Moore, FL;Schreck, CB
本研究探讨了促肾上腺皮质激素释放激素（CRH）的行为效应，在少年春奇努克鲑鱼，Oncorhynchus tshawytscha的介导的肾上腺皮质激素能系统是否参与。侧脑室（ICV）注射CRH诱导多动症。CRH的作用以剂量依赖性方式通过同时给予5-羟色胺（5-HT）选择性再摄取抑制剂氟西汀而增强。然而，氟西汀单独给药对自发活动没有影响，这表明CRH的自发刺激作用是由多巴胺能系统的激活介导的。相反，ICV注射5-HT 1A受体拮抗剂NAN-190减弱了CRH与CRH联合给药时对自发活动的影响，但单独给药时没有影响。这些结果提供了第一个证据，以支持这一假设，CRH对运动活动的硬骨鱼类的影响是通过激活神经元能系统介导的。(C)2003 Elsevier Science（美国）。All rights reserved.
The present study investigated whether the serotonergic system is involved in mediating the behavioral effects of corticotropin-releasing hormone (CRH) in juvenile spring chinook salmon, Oncorhynchus tshawytscha. An intracerebroventricular (ICV) injection of CRH induced hyperactivity. The effect of CRH was potentiated in a dose-dependent manner by the concurrent administration of the serotonin (5-HT) selective reuptake inhibitor fluoxetine. However, administration of fluoxetine alone had no effect on locomotor activity, suggesting that the locomotor-stimulating effect of CRH is mediated by the activation of the serotonergic system. Conversely, ICV injections of the 5-HT1A receptor antagonist NAN-190 attenuated the effect of CRH on locomotor activity when given in combination with CRH but had no effect when administered alone. These results provide the first evidence to support the hypothesis that the effect of CRH on locomotor activity in teleosts is mediated by activating the serotonergic system. (C) 2003 Elsevier Science (USA). All rights reserved.