Serum phosphate levels reflect responses to cardiac resynchronization therapy in chronic heart failure patients
Serum phosphate levels reflect responses to cardiac resynchronization therapy in chronic heart failure patients
复制标题
血清磷酸盐水平反映慢性心力衰竭患者对心脏再同步治疗的反应
DOI：
10.1016/j.joa.2014.06.006
复制
发表时间：
2015
影响因子：
2
通讯作者：
Takeishi Y
中科院分区：
文献类型：
--
作者：
Kamiyama Y;Suzuki H;Yamada S;Kaneshiro T;Takeishi Y
背景最近的研究表明，高水平的血清磷酸盐与不良心血管事件有关。然而，对于接受心脏再同步治疗（CRT）的慢性心力衰竭（CHF）患者的磷酸盐水平与心功能改善之间的关系知之甚少。本研究的目的是检查血清磷酸盐水平是否能够预测 CRT 的反应者和不良心脏事件。 方法 研究人群包括 30 名接受植入除颤器 (CRT-D) 的 CRT 的 CHF 患者（24 名男性，平均年龄 65.7±8.5 岁）。在 CRT-D 植入前和植入后 6 个月测量血清磷酸盐水平。通过超声心动图同时评估左心室舒张末期容积和收缩末期容积。此外，还调查了因心力衰竭恶化而再次住院的比率。所有患者被分为 2 组：对 CRT-D 有反应者（R 组，n=18）和无反应者（NR 组，n=12）。有反应者被定义为左心室收缩末期容积减少 >15% 的患者。我们比较了 2 组之间的这些参数。结果 R 组的血清磷酸盐水平显着低于 NR 组（3.3±0.2 vs. 3.7±0.4 mg/dL，p=0.01）。 R 组的再住院率低于 NR 组（0% vs. 33%，p=0.018）。多变量分析表明，血清磷酸盐水平具有预测 CRT 反应者的能力（比值比 0.008，95% 置信区间 0.000–0.348，p=0.015）。 结论这些结果表明，血清磷酸盐水平可能预测接受 CRT-D 的 CHF 患者的 CRT 反应者和不良心脏事件。
BackgroundRecent studies have shown that high levels of serum phosphate are associated with adverse cardiovascular events. However, little is known about the relation between phosphate levels and improvement of cardiac function in chronic heart failure (CHF) patients who underwent cardiac resynchronization therapy (CRT). The purpose of this study was to examine whether serum phosphate levels were able to predict responders to CRT and adverse cardiac events.MethodsThe study population consisted of 30 CHF patients (24 males, mean age 65.7±8.5 years) who received CRT with defibrillator (CRT-D) implantation. Levels of serum phosphate were measured before, and 6 months after, CRT-D implantation. Left ventricular end-diastolic volume and end-systolic volume were assessed simultaneously by echocardiography. In addition, the rate of re-hospitalization due to worsening of heart failure was investigated. All patients were divided into 2 groups: responders (Group-R,n=18) and non-responders (Group-NR,n=12) to CRT-D. Responders were defined as patients who showed >15% reduction in left ventricular end-systolic volume. We compared these parameters between the 2 groups.ResultsSerum phosphate levels were significantly lower in Group-R than in Group-NR (3.3±0.2 vs. 3.7±0.4 mg/dL,p=0.01). The rate of re-hospitalization was lower in Group-R than in Group-NR (0% vs. 33%,p=0.018). Multivariate analysis showed that serum phosphate levels had a predictive power to determine responders to CRT (odds ratio 0.008, 95% confidence interval 0.000–0.348,p=0.015).ConclusionsThese results suggest that serum phosphate levels might predict both responders to CRT, and adverse cardiac events, in CHF patients with CRT-D.
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DOI：
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发表时间：
2012
期刊：
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作者：
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通讯作者：
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影响因子：
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作者：
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DOI：
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DOI：
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发表时间：
2021
期刊：
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作者：
Withycombe,JaniceS;Carlson,Aimee;Coleman,Carly;Leslie,SharonL;Skeens,Micah;Tseitlin,Hanna;Duffy,ElizabethA
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