Mechanisms and regulation of autophagosome formation
Mechanisms and regulation of autophagosome formation
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DOI：
10.1016/j.ceb.2012.05.001
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发表时间：
2012-08-01
影响因子：
7.5
通讯作者：
Martens, Sascha
中科院分区：
文献类型：
--
作者：
Kraft, Claudine;Martens, Sascha
自噬是细胞内大量降解胞质物质如胞质溶胶、蛋白质聚集体和细胞器的途径。自噬的特征在于形成称为自噬体的双膜结合囊泡，其吞噬货物并将其运输到液泡/溶酶体进行分解和回收。尽管已经鉴定了该途径中的几种蛋白质，但对这些蛋白质在自噬体生物发生过程中的作用机制知之甚少。在这篇综述中，我们简要讨论了最近的研究结果的分子球员和机制参与自噬体的形成。特别是，我们将专注于调节膜的招聘机制，以及自噬体形成过程中的膜重塑。
Autophagy is an intracellular pathway for the bulk degradation of cytoplasmic substances such as cytosol, protein aggregates and organelles. Autophagy is characterized by the formation of double-membrane bound vesicles called autophagosomes, which engulf the cargo and transport it to the vacuole/lysosome for breakdown and recycling. Even though several proteins in this pathway have been identified, little is known about the mechanism of action of these proteins during autophagosome biogenesis. In this review we briefly discuss recent findings on the molecular players and mechanisms involved in autophagosome formation. In particular, we will focus on the mechanisms regulating membrane recruitment as well as membrane remodeling during autophagosome formation.