GENE-EXPRESSION IN PREIMPLANTATION MAMMALIAN EMBRYOS
GENE-EXPRESSION IN PREIMPLANTATION MAMMALIAN EMBRYOS
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DOI：
10.1016/0165-1110(92)90029-9
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发表时间：
1992-12-01
期刊：
影响因子：
--
通讯作者：
HEYNER, S
中科院分区：
文献类型：
--
作者：
SCHULTZ, GA;HEYNER, S
植入前的哺乳动物胚胎最初是在卵子发生过程中积累的母体信息大分子的控制下。随后，发育的遗传程序变得依赖于源自胚胎基因组激活的新转录。几种胚胎转录物，包括那些编码生长因子，细胞连接组件和质膜离子转运蛋白是胚胎正常发育到胚泡阶段所必需的。基因表达的模式和发育的总体程序受到基因组印记的影响以及胚胎在母体生殖道内遇到的外部影响。
The pre-implantation mammalian embryo is initially under the control of maternal informational macromolecules that are accumulated during oogenesis. Subsequently, the genetic program of development becomes dependent upon new transcription derived from activation of the embryonic genome. Several embryonic transcripts including those that encode growth factors, cell junction components and plasma membrane ion transporters are required for normal progression of the embryo to the blastocyst stage. The pattern of genes expressed and the overall program of development is subject to the influences of genomic imprinting as well as external influences encountered by the embryo within the maternal reproductive tract.