Diffusion tensor fiber tracking shows distinct Corticostriatal circuits in humans
Diffusion tensor fiber tracking shows distinct Corticostriatal circuits in humans
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DOI：
10.1002/ana.20030
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发表时间：
2004-04-01
影响因子：
11.2
通讯作者：
Kim, DS
中科院分区：
文献类型：
--
作者：
Lehéricy, S;Ducros, M;Kim, DS
非人类灵长类皮质纹状体连接的一个里程碑是，皮质连接被组织成一组离散的电路。假设每个电路执行不同的行为功能。在动物中，大多数连接性研究都是使用侵入性追踪方法进行的，这在人类中是不适用的。为了验证皮质纹状体连接在人类中被组织为多个回路的提议，我们使用了弥散张量成像轴突追踪，这是一种新的磁共振技术，可以以非侵入性的方式展示纤维束。基于弥散张量成像的纤维追踪显示，人类纹状体的后部（感觉运动）、前部（联想）和腹侧（边缘）隔室与皮质有特定的联系，特别是额叶。这些结果首次直接证明了人类皮质纹状体的不同联系。
A landmark of corticostriatal connectivity in nonhuman primates is that cortical connections are organized into a set of discrete circuits. Each circuit is assumed to perform distinct behavioral functions. In animals, most connectivity studies are performed using invasive tracing methods, which are nonapplicable in humans. To test the proposal that corticostriatal connections are organized as multiple circuits in humans, we used diffusion tensor imaging axonal tracking, a new magnetic resonance technique that allows demonstration of fiber tracts in a noninvasive manner. Diffusion tensor imaging-based fiber tracking showed that the posterior (sensorimotor), anterior (associative), and ventral (limbic) compartments of the human striatum have specific connections with the cortex, and particularly the frontal lobes. These results provide the first direct demonstration of distinct corticostriatal connections in humans.